中国中西医结合外科杂志2026，Vol.32Issue(1)：35-39,5.DOI:10.3969/j.issn.1007-6948.2026.01.007
白头翁汤合芍药汤加减联合灌肠治疗大肠湿热型溃疡性结肠炎的临床疗效
Clinical effect of the modified combination of Baitouweng decoction and Shaoyao decoction for enema treatment on ulcerative colitis with large intestine damp-heat
摘要
Abstract
Objective To explore the clinical efficacy of the modified combination of Baitouweng decoction and Shaoyao decoction plus or minus for enema treatment on ulcerative colitis with large intestine damp-heat.Methods A total of 96 ulcerative colitis with large intestine damp-heat patients admitted to our hospital from January 2023 to January 2025 were selected and divided into the oral administration group(n=48)and the combined group(n=48)according to the random number method.Patients in the oral administration group received modified oral administration of Baitouweng decoction and Shaoyao decoction plus or minus,while those in the combined administration group received addition enema treatment of Baitouweng decoction and Shaoyao decoction plus or minus on the basis of the treatment in the oral administration group.Comparing clinical efficacy of the two groups,the TCM symptom scores before and after treatment,the Baron endoscopic score,the modified Mayo activity index,the related indicators of serum intestinal mucosal barrier function,serum inflammatory factor levels as well as the adverse reaction occurrences.Results The total effective rate of the combined group was higher than that of the oral administration group(P＜0.05).After treatment,the scores of various traditional Chinese medicine symptoms,Baron endoscopic score,modified Mayo activity index,serum intestinal mucosal barrier function-related indicators DAO,D-lactic acid,ET,and the levels of IL-6 and TNF-α in both groups were lower compared with before,with lower in the combined group than the oral administration group(P＜0.05).The level of IL-10 was higher than that before treatment,while the combined group was higher than the oral administration group(P＜0.05).No statistically significant difference was found in the occurrence of adverse reactions between the two groups(P=0.296).Conclusion The modified combination of Baitouweng decoction and Shaoyao decoction plus or minus for enema treatment can effectively treat ulcerative colitis of damp-heat type in the large intestine.关键词
白头翁汤合芍药汤/大肠湿热型溃疡性结肠炎/灌肠治疗/加减治疗Key words
Baitouweng decoction and Shaoyao decoction/ulcerative colitis with large intestine damp-heat/enema therapy/modified treatment分类
医药卫生引用本文复制引用
俞欢,吴婷婷..白头翁汤合芍药汤加减联合灌肠治疗大肠湿热型溃疡性结肠炎的临床疗效[J].中国中西医结合外科杂志,2026,32(1):35-39,5.基金项目
江苏省科技项目(BK20201179) （BK20201179）
苏州市科技计划项目(SYW2024128) （SYW2024128）
