中国中西医结合外科杂志2026，Vol.32Issue(1)：40-44,5.DOI:10.3969/j.issn.1007-6948.2026.01.008
直肠炎灌肠方直肠滴入治疗溃疡性直肠炎的疗效及对血清白细胞介素-10、单核细胞趋化蛋白-1水平的影响
Therapeutic effect of self-made proctitis enema via rectal drip on ulcerative proctitis and its influence on serum interleukin-10 and monocyte chemoattractant protein-1 levels
摘要
Abstract
Objective To investigate the healing effect of a self-made proctitis enema formula rectal instillation combined with mesalazine enteric coated tablets in treating ulcerative proctitis(UP)and its impacts on levels of serum interleukin-10(IL-10)and monocyte chemoattractant protein-1(MCP-1).Methods Selecting 90 patients with UP who were treated in our hospital from March 2021 to December 2023,and were divided into treatment group(treatment plan:self-designed proctitis enema prescription combined with mesalazine enteric-coated tablets)and control group(treatment plan:mesalazine enteric-coated tablets)by random number table method,45 cases each.The healing effect,inflammatory factors,intestinal barrier function indicators,traditional Chinese medicine syndrome scores,colonoscopy scores,inflammatory bowel disease questionnaire(IBDQ)scores,and adverse reactions of the two groups were compared.Results The total effective rate of the treatment group was higher than that of the control group(95.56％vs 80.00％,P＜0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α)and MCP-1 in both groups decreased compared to before treatment,with a greater decrease observed in the treatment group(P＜0.05);both groups showed an increase in IL-10 level,with a greater increase observed in the treatment group(P＜0.05).After treatment,the levels of diamine oxidase(DAO)and D-lactate in both groups decreased compared to before treatment,with a greater decrease observed in the treatment group(P＜0.05).After treatment,the scores of traditional Chinese medicine syndrome in both groups decreased compared to before treatment,and the decrease was larger in the treatment group(P＜0.05).After treatment,both groups showed a decrease in rectal examination scores compared to before treatment,with the treatment group showing a greater decrease(P＜0.05).Both groups showed an increase in IBDQ scores compared to before treatment,with the treatment group showing a greater increase(P＜0.05).There was no statistically obvious difference in adverse reactions between the two groups(P＞0.05).Conclusion The use of a self-made proctitis enema formula rectal instillation combined with mesalazine enteric coated tablets can improve the clinical symptoms of UP patients,reduce inflammatory reactions,and repair intestinal barrier function,with obvious healing effects.关键词
溃疡性直肠炎/直肠炎灌肠方/美沙拉嗪肠溶片/白细胞介素10/单核细胞趋化蛋白-1Key words
Ulcerative proctitis/proctitis enema formula/mesalazine enteric coated tablets/interleukin-10/monocyte chemoattractant protein-1分类
医药卫生引用本文复制引用
崔书德,李晓华,石杰,马敬华..直肠炎灌肠方直肠滴入治疗溃疡性直肠炎的疗效及对血清白细胞介素-10、单核细胞趋化蛋白-1水平的影响[J].中国中西医结合外科杂志,2026,32(1):40-44,5.基金项目
河北省中医药管理局2021年度中医药类科研计划课题(2021320) （2021320）
