中国中医急症2026，Vol.35Issue(1)：23-27,5.DOI:10.3969/j.issn.1004-745X.2026.01.005
表里井穴刺血法对脂多糖致热家兔前列腺素E2水平的影响
Effects of Bloodletting Therapy at Exterior-Interior Jing Acupoints on Prostaglandin E2 Levels in Rabbits with LPS-Induced Fever
摘要
Abstract
Objective:To explore the antipyretic mechanism of bloodletting therapy at exterior-interior Jing acu-points.Methods:30 male rabbits were randomly divided into normal group,model group,Shaoshang group,Shang-yang group and Shaoshang-Shangyang group.An exogenous fever model was established by intravenous injection of lipopolysaccharide(LPS).After successful modeling,bloodletting therapy was performed at bilateral Shaoshang acupoint,bilateral Shangyang acupoint,and bilateral Shaoshang plus Shangyang acupoint respectively.The anti-pyretic mechanism was explored by analyzing the levels of prostaglandin E2(PGE2)and cyclooxygenase-2(COX-2)in serum and brain tissue of rabbits in each group after intervention.Results:Compared with the model group,the anal temperature of rabbits in the Shaoshang group,Shangyang group and Shaoshang-Shangyang group de-creased with statistical significance(P＜0.01).Compared with the normal group,there was no statistical difference in the anal temperature of rabbits in the Shaoshang group,Shangyang group and Shaoshang-Shangyang group(P＞0.05).Compared with the model group,the serum PGE2 level of rabbits in the Shaoshang group decreased with statistical significance(P＜0.05),and that in the Shaoshang-Shangyang group decreased with significant statistical significance(P＜0.01).The brain tissue PGE2 level of rabbits in the Shangyang group decreased with significant statistical significance(P＜0.01),and that in the Shaoshang-Shangyang group decreased with statistical significance(P＜0.05).The hypothalamic COX-2 level of rabbits in the Shaoshang group decreased with significant statistical significance(P＜0.01),and that in the Shangyang group and Shaoshang-Shangyang group decreased with statisti-cal significance(P＜0.05).Conclusion:Bloodletting therapy at Shaoshang and Shangyang acupoint may exert an antipyretic effect by inhibiting the COX-2/PGE2 signaling pathway and reducing the release of central and periph-eral pyrogenic mediators.关键词
外感发热/少商穴/商阳穴/前列腺素E2/环氧化酶-2/兔Key words
Exogenous fever/Shaoshang point/Shangyang point/Prostaglandin E2/Cyclooxygenase-2/Rabbits分类
医药卫生引用本文复制引用
付跃峰,吴京秦,寇男,冯婧,程淑莉,郭楠,刘红栓,张庆..表里井穴刺血法对脂多糖致热家兔前列腺素E2水平的影响[J].中国中医急症,2026,35(1):23-27,5.基金项目
中华中医药学会雏鹰计划中医临床青年人才研修项目(CYJH2024008) （CYJH2024008）
首都卫生发展科研专项(2024-2-8084) （2024-2-8084）
北京中医药大学东直门医院临床研究和成果转化能力提升试点项目(DZMG-TZZX-24011) （DZMG-TZZX-24011）
