摘要
Abstract
Objective To investigate the emergency treatment efficacy of penehyclidine hydrochloride combined with atropine in patients with acute organophosphorus pesticide poisoning(AOPP)and its impact on myocardial enzyme profiles.Methods A retrospective analysis was conducted on the clinical data of 70 AOPP patients admitted to Sanming Second Hospital from April 2022 to July 2024.Based on the actual emergency medications used,they were divided into a study group(35 cases,penehyclidine hydrochloride combined with atropine)and a control group(35 cases,atropine alone).The emergency treatment efficacy,levels of myocardial enzymes[creatine kinase(CK),creatine kinase-MB(CK-MB),lac-tate dehydrogenase(LDH)],time for cholinesterase(CHE)to return to normal,hospital stay,adverse reactions,endpoint outcomes,and medication dosage were compared between the two groups.Results The total effective rate of emergency treatment in the study group was significantly higher than that in the control group(94.29%vs.74.29%,P=0.022).Before treatment,there was no significant difference in CK,CK-MB,and LDH levels between the two groups(P>0.05).After treatment,the levels of these myocardial enzymes significantly decreased in both groups,with the study group showing sig-nificantly lower levels of CK(P<0.001),CK-MB(P<0.001),and LDH(P<0.001)compared to the control group.The time for CHE to return to normal(P<0.001)and hospital stay(P<0.001)were significantly shorter in the study group than in the control group.There was no significant difference in the total incidence of adverse reactions between the two groups(31.43%vs.42.86%,P=0.322).The incidenc-es of rebound phenomenon,mechanical ventilation,mortality,and intermediate syndrome in the study group were significantly lower than those in the control group(P<0.05).Conclusion Penehyclidine hydrochloride combined with atropine can effectively improve the emergency treat-ment efficacy for AOPP patients,ameliorate myocardial enzyme profiles,promote CHE recovery,shorten hospital stay,and reduce the risk of severe adverse outcomes such as rebound phenomenon,mechanical ventilation,and death,offering supe-rior clinical benefits.关键词
盐酸戊乙奎醚/阿托品/急性有机磷农药中毒Key words
penehyclidine hydrochloride/atropine/acute organophosphorus pesticide poisoning
