肿瘤防治研究2026，Vol.53Issue(1)：43-49,7.DOI:10.3971/j.issn.1000-8578.2026.25.0569
TAM脂质代谢调控:从细胞内重编程到系统性代谢网络
Lipid Metabolism Regulation in TAM:From Cellular Reprogramming to Systemic Metabolic Networks
摘要
Abstract
Tumor-associated macrophages(TAMs)have become the core hub connecting the local microenvironment and system metabolism through lipid metabolism reprogramming.By enhancing lipid uptake and lipophagy-mediated cholesterol redistribution,TAMs support tumor cell membrane synthesis,signaling activation,and invasive potential.Immune checkpoints upregulation driven by peroxisome proliferator-activated receptor γ,nutrient deprivation,and adenosine production contribute to the formation of an immunosuppressive niche.At the systemic level,tumors orchestrate a bidirectional,lipid-mobilizing network by activating hepatic sterol regulatory element-binding protein-1c and promoting adipose tissue lipolysis,with TAMs serving as key intermediaries in this process.The organ-specific features of TAM lipid metabolism shaped by distinct tumor microenvironments suggest that therapeutic strategies should consider tissue context.Integrating metabolomic biomarkers,dietary interventions,and combination immunotherapies holds promise for achieving precision metabolic immunotherapy.关键词
脂质负载巨噬细胞/肿瘤微环境/脂质代谢/脂质网络/靶向治疗/协同疗法Key words
Lipid-laden macrophages/Tumor microenvironment/Lipid metab-olism/Lipid network/Targeted therapy/Combination therapy分类
医药卫生引用本文复制引用
李宇轩,李昀徽,任欢..TAM脂质代谢调控:从细胞内重编程到系统性代谢网络[J].肿瘤防治研究,2026,53(1):43-49,7.基金项目
广东省教学质量与教学改革工程建设项目(SJZLGC202313) （SJZLGC202313）
国家自然科学基金面上项目(81871-993) （81871-993）
南方科技大学大学生创新项目(Y25411800) Guangdong Province Teach-ing Quality and Teaching Reform Project(No.SJZLGC202313) （Y25411800）
General Project of National Natural Science Foundation of China(No.81871993) （No.81871993）
Southern University of Science and Technology Student Innovation Project(No.Y25411800) （No.Y25411800）
