肿瘤防治研究2026，Vol.53Issue(1)：50-59,10.DOI:10.3971/j.issn.1000-8578.2026.25.0430
卵巢癌中LIPG的表达与铂类耐药性和预后相关
LIPG Expression in Ovarian Cancer is Associated with Platinum Resistance and Prognosis
摘要
Abstract
Objective To investigate the expression of endothelial lipase(LIPG)in ovarian cancer(OC)and its association with platinum resistance and patient prognosis.Methods Transcriptomic and clinical data were obtained from TCGA database and validated using clinical OC specimens.LIPG expression was ass-essed by quantitative real-time PCR and immunohistochemistry.Protein-protein interaction analysis,functi-onal enrichment,and regression modeling were performed to assess the impact of the relevant genes on progn-osis and platinum-based chemotherapy response,and a predictive model was subsequently constructed by incorporating immune infiltration characteristics.Results Fifteen LIPG-differential genes were identified,mainly enriched in lipid metabolism pathways.High LIPG expression was significantly associated with shor-tened overall survival and progression-free survival.APOA5,LIPG,and PNLIPRP3 were confirmed as inde-pendent predictors via multivariate regression analysis,and their combined model showed good performance in predicting platinum response.Immune analysis revealed that high-risk patients exhibited downregulated antigen presentation,increased CD8+T cell and dendritic cell infiltration,and reduced macrophage and regulatory T cell proportions.Clinical validation further confirmed that platinum-resistant patients had significantly increased LIPG mRNA and protein expression levels.Conclusion High LIPG expression is closely associated with poor prognosis and platinum resistance in OC.A multi-gene risk model incorporating LIPG improves predictive accuracy,and LIPG may serve as a potential biomarker and therapeutic target of ovarian cancer.关键词
卵巢癌/铂类耐药/LIPG/预后Key words
Ovarian cancer/Platinum resistance/LIPG/Prognosis分类
医药卫生引用本文复制引用
秦晨,邱培圆,邓茜韩,李力..卵巢癌中LIPG的表达与铂类耐药性和预后相关[J].肿瘤防治研究,2026,53(1):50-59,10.基金项目
National Natural Science Foundation of China(No.82160450) 国家自然科学基金(82160450) （No.82160450）
