肿瘤防治研究2026，Vol.53Issue(1)：60-72,13.DOI:10.3971/j.issn.1000-8578.2026.25.0604
靶向近红外荧光探针在肿瘤中的作用
Role of Targeted Near-Infrared Fluorescent Probes in Tumors
摘要
Abstract
Targeted near-infrared fluorescence(NIRF)probes have garnered widespread attention because of their unique advantages in early tumor diagnosis,intraoperative navigation,and personalized therapy.NIRF offers strong tissue penetration,low background interference,and minimal phototoxicity,which make it an ideal tool for in vivo molecular imaging.By conjugating NIRF dyes with high-affinity targeting groups,these probes can specifically recognize tumor-associated biomarkers(such as folate receptor,prostate-specific membrane antigen,human epidermal growth factor receptor 2,epidermal growth factor receptor,carcinoembryonic antigen,etc.),which enhanced fluorescence signal intensity and contrast in tumor regions.With the continuous optimization of fluorescent dyes and upgrading of targeting groups,the applications of targeted NIRF probes in various malignant tumors are expanding,showing great potential in tumor intraoperative imaging,diagnostic imaging,and therapy.This review summarizes recent advances in targeted NIRF probes,with a focus on structural improvements,preclinical studies,and early clinical applications.关键词
近红外荧光探针/靶向成像/术中导航/影像检查/光动力治疗/光热治疗Key words
Near-infrared fluorescent probes/Targeted imaging/Intraoperative navigation/Diagnostic imaging/Photodynamic therapy/Photothermal therapy分类
医药卫生引用本文复制引用
沈玉兰,叶虎男,周欢欢,马赛莹,李佳莹,王佳,王晓稼..靶向近红外荧光探针在肿瘤中的作用[J].肿瘤防治研究,2026,53(1):60-72,13.基金项目
2023 Zhejiang Provincial Basic Public Welfare Research Program(No.TGD-23H160003) 2023年浙江省基础公益研究计划课题(TGD-23H160003) （No.TGD-23H160003）
