北京大学学报（医学版）2026，Vol.58Issue(1)：74-83,10.DOI:10.19723/j.issn.1671-167X.2026.01.010
异种骨与人工合成骨在磨牙拔牙同期微翻瓣牙槽嵴保存术中的临床效果比较
Clinical comparison of xenograft versus synthetic bone graft materials in micro crestal flap-alveolar ridge preservation following extraction of molars
摘要
Abstract
Objective:To compare the clinical outcomes between xenogeneic bone graft materials pri-marily composed of deproteinized bovine bone mineral(DBBM)and synthetic bone graft materials prima-rily composed of hydroxyapatite(HA)used in micro crestal flap-alveolar ridge preservation(MCF-ARP)of periodontally compromised molars,so as to provide a reference for their application and promotion.Methods:In this retrospective case series study,patients who received treatment between October 2024 and April 2025 were enrolled.All the patients underwent MCF-ARP,using either DBBM or HA.Hard tissue changes and alveolar ridge contour collapse were evaluated and compared between the two groups preoperatively and 6 months postoperatively using cone beam computed tomography(CBCT)and intraoral scanning.Soft tissue healing process after the surgery was also assessed.Results:A total of 14 molars from 14 patients were included.No significant differences were found in hard tissue changes between the two groups 6 months after the surgery(P＞0.05).Two weeks and 1 month postoperatively,the vertical collapse of the contour at the ridge center was significantly greater in the HA group compared with the DBBM group[2 weeks:(2.73±1.89)mm vs.(0.00±0.79)mm,P＜0.05;1 month:(2.74±1.13)mm vs.(0.35±2.34)mm,P＜0.05].No significant differences were found in other sites at any other follow-up points(P＞0.05).In terms of wound healing,the HA group showed a significantly higher percentage of wound area lacking keratinized tissue coverage compared with the DBBM group both 2 weeks and 1 month after the surgery(2 weeks:47.88％±6.56％vs.29.43％±14.25％,P＜0.05;1 month:25.68％±13.06％vs.7.19％±7.18％,P＜0.01).Conclusion:Within the limitations of this study,the analysis suggests that there is no statistically significant difference in hard tissue and alveo-lar ridge contour parameters 6 months after MCF-ARP following extraction of periodontally compromised molars.However,early soft tissue healing is faster when using DBBM.Future randomized controlled trials with histological analysis are warranted for further validation.关键词
牙周炎/牙槽嵴保存术/牙槽骨移植/异种移植物Key words
Periodontitis/Alveolar ridge preservation/Alveolar bone grafting/Heterografts分类
医药卫生引用本文复制引用
张斯巧,刘建,徐涛,胡文杰,张浩筠,危伊萍..异种骨与人工合成骨在磨牙拔牙同期微翻瓣牙槽嵴保存术中的临床效果比较[J].北京大学学报（医学版）,2026,58(1):74-83,10.基金项目
北京大学口腔医(学)院临床研究基金(PKUSS-2023CRF505)Supported by the Clinical Research Foundation of Peking University School and Hospital of Stomatology(PKUSS-2023CRF505) （学）
