重庆医学2026，Vol.55Issue(1)：141-144,149,5.DOI:10.3969/j.issn.1671-8348.2026.01.024
新疆伊犁州624例育龄女性MTHFR C677T基因的多态性分析
Analysis on MTHFR C677T gene polymorphism in 624 women of childbearing age in Yili Kazak Autonomous Prefecture
摘要
Abstract
Objective To investigate the distribution of methylenetetrahydrofolate reductase(MTH-FR)C677T gene polymorphisms and its regional genetic characteristics among the women of childbearing age in Yili Kazak Autonomous Prefecture of Xinjiang(Yili Prefecture),and to compare the differences in the gene frequencies between Han nationality and other ethnic minorities in order to provide the genetic references for rationally guiding folic acid supplementation in the women of childbearing age.Methods A total of 624 women of childbearing age who went to this hospital for pre-pregnancy and pregnancy check-ups from August 2023 to November 2024 were selected as the study subjects.The polymorphisms at MTHFR C677T gene locus conducted the precise determination by the real-time fluorescence quantitative PCR.The genotypes and allele frequencies conducted the statistics and comparative analysis with the data of the other regions.Results Among 624 women of childbearing age,the CC,CT and TT genotypes frequencies in MTHFR C677T gene polymorphisms were 33.8%,45.4%and 20.8%respectively,the alleles C and T were 56.5%and 43.5%,respectively,and the differences in the gene frequencies of women of childbearing age between Han Chinese and those of other ethnic minorities in Yili Prefecture were statistically significant(P<0.05).Conclusion The distribution of MTHFR C677T gene polymorphisms among the women of childbearing age in Yili Prefecture has the territory speciality.About 70%of women of childbearing age are the CT and TT genotypes.There is the potential threat of folic acid metabolic abnormality.关键词
亚甲基四氢叶酸还原酶基因/遗传变异/C677T位点/叶酸代谢Key words
methylenetetrahydrofolate reductase gene/genetic variation/C677T locus/folate metabo-lism分类
医药卫生引用本文复制引用
李浩然,田海鸿,迪丽娜孜·艾尔肯,吕春芳..新疆伊犁州624例育龄女性MTHFR C677T基因的多态性分析[J].重庆医学,2026,55(1):141-144,149,5.基金项目
伊犁哈萨克自治州科技计划项目(YJC2023A38). （YJC2023A38）
