湖南中医杂志2026，Vol.42Issue(1)：64-68,5.DOI:10.16808/j.cnki.issn1003-7705.2026.01.014
振痿汤联合他达拉非治疗肾阳虚型勃起功能障碍40例
Clinical effect of Zhenwei Decoction combined with tadalafil in treatment of erectile dysfunction with kidney Yang deficiency:An analysis of 40 cases
摘要
Abstract
Objective:To investigate the clinical effect of Zhenwei Decoction combined with tadalafil in the treatment of erectile dysfunction(ED)with kidney Yang deficiency and its effect on nitric oxide(NO)and testosterone(T).Methods:A total of 80 ED patients with kidney Yang deficiency were randomly divided into treatment group and control group,with 40 patients in each group.The patients in the control group were given tadalafil alone,while those in the treat-ment group were given Zhenwei Decoction in addition to the treatment in the control group,and the course of treatment was 8 weeks for both groups.The two groups were compared in terms of International Index of Erectile Function-5(IIEF-5)score,Erection Hardness Score(EHS),traditional Chinese medicine(TCM)syndrome score,the levels of NO and T,and adverse reactions,and clinical outcome was assessed.Results:There was a significant difference in overall response rate between the treatment group and the control group[80.00％(32/40)vs 67.50％(27/40),P＜0.05].After treatment,both groups had significant changes in IIEF-5 score,EHS,and NO level,and there were significant differences in these indicators between the two groups after treatment(P＜0.05).There was no significant change in the level of T in either group after treatment,and there was no significant difference in the level of T between the two groups after treat-ment(P＞0.05).The treatment group had a significant change in TCM syndrome score after treatment,and there was a significant difference in TCM syndrome score between the two groups after treatment(P＜0.05),while there was no significant change in TCM syndrome score in the control group after treatment(P＞0.05).There was no significant dif-ference in the incidence rate of adverse reactions between the treatment group and the control group[15.00％(6/40)vs 12.50％(5/40),P＞0.05].Conclusion:Zhenwei Decoction combined with tadalafil can improve erectile function and clinical symptoms in ED patients with kidney Yang deficiency in a synergistic manner and has a favorable safety profile,and therefore,it holds promise for clinical application.关键词
勃起功能障碍/肾阳虚型/中西医结合疗法/振痿汤/他达那非Key words
erectile dysfunction/kidney Yang deficiency/integrated traditional Chinese and Western medicine therapy/Zhenwei Decoction/tadalafil引用本文复制引用
夏康,庞然,莫君甫,吴朝奎,李道端..振痿汤联合他达拉非治疗肾阳虚型勃起功能障碍40例[J].湖南中医杂志,2026,42(1):64-68,5.基金项目
重庆市北碚区国家区域医疗中心建设项目(2024qyylzx-05) （2024qyylzx-05）
