湖南中医杂志2026，Vol.42Issue(1)：171-178,8.DOI:10.16808/j.cnki.issn1003-7705.2026.01.030
SIRT3在高脂血症和血管内皮功能损伤中的研究进展
Research advances in SIRT3 in hyperlipidemia and vascular endothelial function impairment
摘要
Abstract
SIRT3 is an enzyme located in the mitochondria that has stable mitochondrial deacetylation activity.It regulates mitochondrial proteins through deacetylation and plays a crucial role in maintaining redox balance,regulating energy metabolism,and modulating mitochondrial dynamics.SIRT3 can improve vascular endothelial function by regu-lating mitochondrial function,and maintenance of vascular endothelial function is a key link in the prevention and treat-ment of hyperlipidemia.Therefore,it is of great importance to explore the effect of SIRT3 in the prevention and treatment of hyperlipidemia by analyzing its impact on vascular endothelial function.Meanwhile,with reference to the traditional Chinese medicine etiology and pathogenesis of hyperlipidemia and vascular endothelial injury,this article proposes the hypothesis that the change in SIRT3 is associated with viscera/bowels,Qi-blood,and Yin/Yang in traditional Chinese medicine,which may provide new ideas of integrated traditional Chinese and Western medicine for theoretical research into the treatment of hyperlipidemia.关键词
高脂血症/血管内皮功能/SIRT3/作用机制/中医理论/综述Key words
hyperlipidemia/vascular endothelial function/SIRT3/mechanism of action/traditional Chinese medi-cine theory引用本文复制引用
张晓艳,张红星,潘小丽..SIRT3在高脂血症和血管内皮功能损伤中的研究进展[J].湖南中医杂志,2026,42(1):171-178,8.基金项目
国家自然科学基金项目(82274663,82405577) （82274663,82405577）
湖北省技术创新计划项目(2024BCB010) （2024BCB010）
