动物医学进展2026，Vol.47Issue(1)：40-46,7.
中国食品动物源1,4,[5],12:i:-沙门氏菌致病性岛、运动性、生物膜形成和大蜡冥致死特征研究
Pathogenic Island Genes,Motility,Biofilm Formation and Galleria mellonella Mortality Characteristics of 1,4,[5],12:i:-Salmonella from Chinese Food Animal Sources
摘要
Abstract
To study the pathogenic island genes,motility,biofilm formation and Galleria mellonella mortality charac-teristics of monophasic variant of S.Typhimurium 4,[5],12:i:-(MVST)in food animals in China.The virulence char-acteristics of MVST were investigated by whole genome sequencing analysis,crystal violet staining to assess biofilm formation,swimming motility test and Galleria mellonella in vivo infection.The results showed that 59 MVST carried 100％Salmonella pathogenic island(SPI)genes,and up to 7 different SPI types.MVST can form biofilm in vitro,and 32.20％have moderate or strong biofilm formation ability.Several MVST had strong swimming ability,with a maxi-mum swimming diameter of 0.93 cm.Most of the 16 isolates presented highly virulent profiles,which led to high mor-tality rates and blackening of Galleria mellonella.In this study,the characteristics of MVST from Chinese food animal sources were investigated from the aspects of gene level,biofilm formation,mobility and mortality rates.The results suggested that the characteristics of MVST were relatively complex,which might be influenced by various different factors.This will provide a basis for surveillance of Salmonella isolates.关键词
1,4,[5],12:i:-沙门氏菌/致病性岛/生物膜/泳动能力/致死率/毒力特征Key words
1,4,[5],12:i:-Salmonella/Pathogenic island/Biofilm/Swimming ability/Mortality rate/Virulence characteristics分类
农业科技引用本文复制引用
沈焕钧,王心远,黄恺祁,许成钢,宋厚辉,蒋红霞,赵秋云..中国食品动物源1,4,[5],12:i:-沙门氏菌致病性岛、运动性、生物膜形成和大蜡冥致死特征研究[J].动物医学进展,2026,47(1):40-46,7.基金项目
浙江省自然科学基金重点项目(Z24C010001):浙江农林大学科研发展基金人才启动基金资助项目(203402009901) （Z24C010001）
浙江农林大学大学生科研训练项目(2024kx0081) （2024kx0081）
