发光学报2026，Vol.47Issue(1)：56-74,19.DOI:10.37188/CJL.20250225
近红外二区激发的有机荧光染料:分子设计、性质与应用
NIR-Ⅱ Excited Organic Fluorophores:Molecular Design,Properties and Applications
摘要
Abstract
The quality of biological fluorescence imaging is determined not only by the emissive brightness of the or-ganic dyes but also by the excitation wavelength.The longer the excited wavelength,the weaker the light-tissue interac-tion,which can reduce photon scattering and effectively lower tissue absorption and autofluorescence.This helps im-prove signal-to-background ratio,spatial and temporal resolution,and penetration depth.Therefore,fluorescence imag-ing excited by the second near-infrared window(NIR-Ⅱ)enables deeper and more precise biological imaging and de-tection,offering greater potential for clinical diagnosis and therapy of diseases.This review first explains the principles and advantages of NIR-Ⅱ fluorescence imaging,then reviews the molecular design strategy and research progress of several important classes of NIR-Ⅱ-excited fluorescent dyes and their applications in medical diagnostics of NIR-Ⅱ flu-orescent probes and the challenges in clinical translation,with an outlook on future development directions.关键词
近红外二区/荧光成像/有机染料/苯并噻二唑Key words
NIR-Ⅱ/fluorescence imaging/organic fluorophores/benzothiadiazole分类
数理科学引用本文复制引用
欧昌金,陈韵如,陶涛..近红外二区激发的有机荧光染料:分子设计、性质与应用[J].发光学报,2026,47(1):56-74,19.基金项目
国家自然科学基金(62575142) （62575142）
江苏省自然科学基金(BK20201389) （BK20201389）
长三角高水平行业特色大学联盟重点课题(CSJZD202407) （CSJZD202407）
江苏省高校青蓝工程(R2018Q03)Supported by National Natural Science Foundation of China(62575142) （R2018Q03）
Natural Science Foundation of Jiangsu Province(BK20201389) （BK20201389）
Key Project of the Yangtze River Delta High-Level Industry-Specific Universities Alliance(CSJZD202407) （CSJZD202407）
The Qing Lan Project of the Jiangsu Higher Education Institutions of China(R2018Q03) （R2018Q03）
