儿科药学杂志2026，Vol.32Issue(2)：40-43,4.DOI:10.13407/j.cnki.jpp.1672-108X.2026.02.010
A型肉毒毒素注射联合任务导向性训练对儿童痉挛型脑性瘫痪疗效研究
Efficacy of Botulinum Toxin Type A Injection Combined with Task-Oriented Training in Children with Spastic Cerebral Palsy
摘要
Abstract
Objective:To observe the effects of botulinum toxin type A(BTX-A)combined with task-oriented training(TOT)in the treatment of spastic cerebral palsy(SCP).Methods:From Dec.2022 to Dec.2024,totally 126 children with SCP were extracted to be divided into BTX-A group,TOT group,and combined group via the sealed envelope randomization,with 42 patients in each group.The BTX-A group was treated with BTX-A injection,the TOT group was given TOT protocol,and the combined group received BTX-AA injection combined with TOT protocol.The efficacy,passive joint range of motion,balance ability,spasticity degree,motor ability and activities of daily living were observed and compared.Results:The total effective rate of combined group was higher than that of BTX-A group and TOT group(P＜0.05).After treatment,the dorsiflexion angle of feet,the Modified Ashworth Scale(MAS)score of ankle joint,and the Composite Spasticity Scale(CSS)score of gastrocnemius muscle in three groups decreased,while the Berg Balance Scale(BBS),the Gross Motor Function Measure(GMFM-88),and the Fugl-Meyer Assessment(FMA)scores increased,the changes in the combined group were more significant(P＜0.05).Conclusion:BTX-A combined with TOT demonstrates significant efficacy in the treatment of SCP,and can significantly improve the symptoms,motor function,and activities of daily living in children.关键词
A型肉毒毒素/任务导向性训练/痉挛型脑性瘫痪/尖足症状/运动功能Key words
botulinum toxin A/task-oriented training/spastic cerebral palsy/tip toe symptoms/motor function分类
医药卫生引用本文复制引用
吉小进,王贵玲,郭锐,李秀丽..A型肉毒毒素注射联合任务导向性训练对儿童痉挛型脑性瘫痪疗效研究[J].儿科药学杂志,2026,32(2):40-43,4.基金项目
邢台市科学技术局资助项目,编号2022ZC220. （）
