影像科学与光化学2026，Vol.44Issue(2)：97-106,10.DOI:10.7517/issn.1674-0475.2026.02.12
T2*mapping序列多亚区评估膝骨性关节炎软骨损伤特征及其与WORMS评分关联
Evalution of the Characteristics of Cartilage Injury in Knee Osteoarthritis and its Association with WORMS Score Using T2*Mapping Sequence with Multiple Subregions
摘要
Abstract
Objective:To evaluate the application value of 3.0T magnetic resonance T2*mapping imaging in multi-subregion assessing of cartilage damage in knee osteoarthritis(KOA).KOA is a common degenerative disease characterized by cartilage degeneration,subchondral bone remodeling,and osteophyte formation,significantly affecting patients'quality of life.Early diagnosis and intervention are crucial for delaying disease progression.Methods:A retrospective analysis was conducted on X-ray,conventional MRI,and T2* mapping image data from 80 patients with KOA in our hospital.Patients were classified according to the severity of their knee osteoarthritis into early KOA(n=54)and advanced KOA(n=26).We analyzed the thickness and T2* values of cartilage,and WORMS cartilage defect scores in various subregions of the knee joint between the two groups.Results:In the analysis of cartilage subzone thickness,the cartilage thickness of the lateral patella,lateral anterior femur,medial anterior femur and tibia,and central zone of the patients in the advanced KOA were lower than those in the early KOA(P<0.05).In the analysis of T2* values of cartilage subregions,11 subregions had elevated T2*values in the advanced KOA group(P<0.05).In addition,the T2*values of the superficial cartilage in each cartilage subregion were significantly higher than those of the deep cartilage in the same subregion(P<0.001).The T2* values of the patellar,medial femur,lateral femur,medial tibia,and lateral tibia cartilage subregions of the patients with KOA showed a mild to strong correlation with WORMS cartilage defect scores(rs=0.401,0.267,0.500,0.624,and 0.582,P<0.05).The AUC of knee cartilage thickness and T2* values of the subregion on the severity of knee osteoarthritis were 0.745 and 0.815,and the AUC of the combined assessment was 0.863.Conclusion:T2*mapping cartilage imaging multi-zone measurements of the knee joint can more accurately identify the site of injury and further quantitatively assess the cartilage damage,providing a more reliable basis for early diagnosis of knee osteoarthritis and targeted intervention.关键词
膝关节/骨性关节炎/关节软骨/磁共振成像/T2*值Key words
knee joint/osteoarthritis/articular cartilage/magnetic resonance imaging/T2*value分类
医药卫生引用本文复制引用
张玲,闫龙,王剑,闫苗苗,黄晓旗,李建龙..T2*mapping序列多亚区评估膝骨性关节炎软骨损伤特征及其与WORMS评分关联[J].影像科学与光化学,2026,44(2):97-106,10.基金项目
延安市重点研发计划一般项目(社会发展领域)(2023SLSFGG-100) （社会发展领域）
北京医学奖励基金会课题研究项目(YXJL-2022-0105-0138). （YXJL-2022-0105-0138）
