影像科学与光化学2026，Vol.44Issue(2)：120-127,142,9.DOI:10.7517/issn.1674-0475.2026.02.15
功能性磁共振成像与光学成像集成在精神疾病高风险人群筛查中的应用前景
Functional Magnetic Resonance Imaging and Optical Imaging Integration in the Screening of High-risk Populations for Mental Disorders
李绪龙 1冯春平 1张富勤2
作者信息
- 1. 达州市达川区人民医院(达州市第三人民医院),四川 635000
- 2. 重庆市第十一人民医院,重庆 400038
- 折叠
摘要
Abstract
Objective:This study aims to explore the effectiveness of integrating functional magnetic resonance imaging(fMRI)and functional near-infrared spectroscopy(fNIRS)in screening high-risk populations for mental disorders,providing a reliable scientific basis for the early intervention of these conditions.Methods:We recruited 60 participants from families with a history of mental disorders and 60 healthy controls,all aged 18～35.fMRI was used to assess the spatial resolution of brain activity,combined with fNIRS to monitor changes in the concentration of oxygenated hemoglobin(HbO)in the prefrontal cortex,thus evaluating the intensity of brain activity.Various methods,including functional connectivity strength(FCS)analysis,independent component analysis(ICA),and small-world property analysis,were used to detect changes in connectivity between different brain regions in high-risk individuals.Results:The integrated imaging approach successfully identified specific brain functional network abnormalities in high-risk individuals,particularly changes in connectivity within the default mode network(DMN)and executive control network(ECN).Compared to the healthy control group,the high-risk group displayed differences in prefrontal cortex activation during cognitive tasks,as well as a significant reduction in the synchronicity of bilateral cortical HbO signals.Conclusion:The integration of functional magnetic resonance imaging and optical imaging technology shows great potential in the early screening of high-risk populations for mental disorders,providing a reliable basis for early intervention.Further development of this method may offer effective tools for clinical screening and early diagnosis.关键词
功能性磁共振成像/光学成像/功能性近红外光谱/精神疾病/早期筛查/神经网络Key words
functional magnetic resonance imaging/optical imaging/functional near-infrared spectroscopy/mental disorders/early screening/neural networks分类
医药卫生引用本文复制引用
李绪龙,冯春平,张富勤..功能性磁共振成像与光学成像集成在精神疾病高风险人群筛查中的应用前景[J].影像科学与光化学,2026,44(2):120-127,142,9.
