影像科学与光化学2026，Vol.44Issue(2)：150-156,7.DOI:10.7517/issn.1674-0475.2026.02.19
术前磁共振腹膜癌指数及CA125在预测卵巢癌热灌注化疗不良结局中的价值研究
The Value of Preoperative MRI Peritoneal Cancer Index and CA125 in Predicting the Adverse Outcome of Hyperthermic Intraperitoneal Chemotherapy for Ovarian Cancer
摘要
Abstract
Objective:To explore the predictive value of preoperative magnetic resonance peritoneal cancer index(MRI-PCI)and CA125 in adverse outcomes of hyperthermic intraperitoneal chemotherapy(HIPEC)for ovarian cancer.Methods:The study collected preoperative MRI-PCI and CA125 data from 60 patients with HIPEC ovarian cancer who received treatment in the Department of Gynecology and Oncology at the Second People's Hospital of Yichang from February 2018 to May 2024.All patients received one HIPEC treatment followed by five cycles of conventional chemotherapy after tumor cell reduction surgery.The study used the date of diagnosis of ovarian cancer as the follow-up starting point and death as the follow-up endpoint,and analyzed the patient's survival time using Kaplan-Meier survival curve.The study analyzed the efficacy of preoperative MRI-PCI and CA125 in predicting adverse outcomes of HIPEC through ROC curve analysis.Results:The median survival time of the patients was 36 months,and a total of 24 patients died during the follow-up period.Based on the maximum Youden's index,the optimal cut-off value for preoperative MRI-PCI was determined to be 8 points.At this time,the sensitivity,specificity,and area under the curve for predicting adverse outcomes of HIPEC were 0.870,0.887,and 0.835,respectively.When the optimal cutoff value of CA125 was 984.38 U/mL,its sensitivity for predicting adverse outcomes of HIPEC was 0.770,specificity was 0.735,and the area under the curve was 0.734.These results indicate that preoperative MRI-PCI demonstrates higher accuracy in predicting adverse outcomes of HIPEC.Conclusion:When preoperative MRI-PCI reaches or exceeds 8 points,the prognosis of ovarian cancer patients is often poor.Compared with CA125,MRI-PCI showed higher efficacy in predicting adverse outcomes of HIPEC.This discovery is of great significance for clinical decision-making,suggesting that the evaluation results of MRI-PCI should be fully considered when formulating treatment plans,in order to provide more personalized and effective treatment for patients.关键词
卵巢癌/腹膜癌/腹膜癌指数/磁共振成像/扩散加权成像Key words
ovarian cancer/peritoneal cancer/peritoneal cancer index/magnetic resonance imaging/diffusion-weighted imaging分类
医药卫生引用本文复制引用
谢晨,邹敏,马天文,郑杰,林国成..术前磁共振腹膜癌指数及CA125在预测卵巢癌热灌注化疗不良结局中的价值研究[J].影像科学与光化学,2026,44(2):150-156,7.基金项目
2023年宜昌市医疗卫生研究项目(A23-1-054). （A23-1-054）
