口腔疾病防治2026，Vol.34Issue(2)：180-190,11.DOI:10.12016/j.issn.2096-1456.202550222
牙龈卟啉单胞菌在肿瘤发生发展中作用的研究进展
Research progress on the role of Porphyromonas gingivalis in the progression of tumor
摘要
Abstract
Periodontitis is a chronic inflammatory disease.The heterotopic colonization of periodontal pathogens re-sults in the development of several systemic diseases.Porphyromonas gingivalis(P.gingivalis),a key pathogen for peri-odontitis,has been linked to the development of various cancers,such as oral squamous cell carcinoma(OSCC),lung cancer,esophageal cancer,pancreatic cancer,colorectal cancer,cervical cancer,and prostate cancer.P.gingivalis pro-mote the progression of tumor through various mechanisms,P.gingivalis regulates proteins targeting cell cycle and apoptosis to promote proliferation of tumor cells directly,enhances tumor stemness by upregulating the expression of cluster of differentiation 44(CD44)and cluster of differentiation 133(CD133),activates inflammasome and p38/c-Jun N-terminal kinase 1(JNK)pathways,regulates tumor-associated neutrophil(TAN)polarization to remodel the tumor mi-croenvironment,regulates epithelial-mesenchymal transition(EMT)to promote tumor metastasis,remodel macrophage function to evade host immune response,and regulates multi-communicating with symbiotic bacteria.In addition,P.gingivalis accelerates the progression of esophageal cancer,pancreatic cancer,colorectal cancer,and prostate cancer by promoting cell proliferation,inhibiting apoptosis,inducing chronic inflammation,and escaping immunity.However,the oral microbiome is a complex system,whether the interactions between oral bacteria affect tumor progression needs to be further investigated.关键词
牙龈卟啉单胞菌/牙周炎/肿瘤/口腔鳞状细胞癌/系统性疾病/菌群失调/致癌机制/早期诊疗/口腔健康Key words
Porphyromonas gingivalis/periodontitis/tumor/oral squamous cell carcinoma/systemic dis-eases/dysbacteriosis/carcinogenic mechanisms/early diagnosis and treatment/oral health分类
医药卫生引用本文复制引用
冯云,冯燕,余丽..牙龈卟啉单胞菌在肿瘤发生发展中作用的研究进展[J].口腔疾病防治,2026,34(2):180-190,11.基金项目
国家自然科学基金项目(82403404) （82403404）
四川省科技计划项目(2024JDRC0040) This study was supported by the grants from the National Natural Science Foundation of China(No.82403404)and the Sichuan Science and Technology Program(No.2024JDRC0040). （2024JDRC0040）
