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PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability

Dandan Zhang Dachun Xu Xiaochen Kou Yanhong Zhao Hong Wang Shaorong Gao Ke Wei Lan Kang Yansong Tang Wen Ye Danli Yang Shengtang Qin Juntao Liu Nan Su Rongrong Huang Guangzheng Shi

国家科学评论(英文版)2026,Vol.13Issue(1):48-63,16.
国家科学评论(英文版)2026,Vol.13Issue(1):48-63,16.DOI:10.1093/nsr/nwaf408

PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability

PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability

Dandan Zhang 1Dachun Xu 2Xiaochen Kou 3Yanhong Zhao 3Hong Wang 4Shaorong Gao 5Ke Wei 1Lan Kang 6Yansong Tang 1Wen Ye 1Danli Yang 7Shengtang Qin 7Juntao Liu 1Nan Su 1Rongrong Huang 2Guangzheng Shi2

作者信息

  • 1. Institute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China
  • 2. Department of Cardiology,Clinical Research Unit,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200092,China
  • 3. Frontier Science Center for Stem Cell Research,Tongji University,Shanghai 200092,China
  • 4. Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China
  • 5. Clinical and Translation Research Center of Shanghai First Maternity & Infant Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China||Frontier Science Center for Stem Cell Research,Tongji University,Shanghai 200092,China
  • 6. Institute for Regenerative Medicine,Shanghai East Hospital,Shanghai Institute of Stem Cell Research and Clinical Translation,Shanghai Key Laboratory of Signaling and Disease Research,Frontier Science Center for Stem Cell Research,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China||Frontier Science Center for Stem Cell Research,Tongji University,Shanghai 200092,China
  • 7. Institute of Cancer Stem Cell,Dalian Medical University,Dalian 116044,China
  • 折叠

摘要

关键词

PKM1/cardiac development/cardiomyocyte proliferation/AMPK/NFYa

Key words

PKM1/cardiac development/cardiomyocyte proliferation/AMPK/NFYa

引用本文复制引用

Dandan Zhang,Dachun Xu,Xiaochen Kou,Yanhong Zhao,Hong Wang,Shaorong Gao,Ke Wei,Lan Kang,Yansong Tang,Wen Ye,Danli Yang,Shengtang Qin,Juntao Liu,Nan Su,Rongrong Huang,Guangzheng Shi..PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability[J].国家科学评论(英文版),2026,13(1):48-63,16.

基金项目

This work was supported by the Key Research and Develop-ment Program,Ministry of Science and Technology of China(2022YFA1103103,2018YFA0800100 and 2017YFA0105600),the National Natural Science Foundation of China(32370870,32070823,32170801 and 92168205),the China Postdoctoral Science Foundation(BX20240261)and the Fundamental Re-search Funds for the Central Universities(22120250336,22120230471 and 22120250374). (2022YFA1103103,2018YFA0800100 and 2017YFA0105600)

国家科学评论(英文版)

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