广州中医药大学学报2026，Vol.43Issue(2)：328-334,7.DOI:10.13359/j.cnki.gzxbtcm.2026.02.007
纳达合剂对慢性萎缩性胃炎伴胆汁反流患者胃肠道激素及免疫炎症因子的影响
Effects of Nada Mixture on Gastrointestinal Hormones and Immunoinflammatory Factors in Patients with Chronic Atrophic Gastritis Accompanied by Bile Reflux
摘要
Abstract
Objective To investigate the effects of Nada Mixture(composed of Haematitum,calcined Endoconcha Sepiae,Hibisci Mutabilis Folium,prepared Rhei Radix et Rhizoma,Scutellariae Radix,Aurantii Fructus Immaturus,Glehniae Radix,Ophiopogonis Radix,Cyperi Rhizoma,Curcumae Radix,Pinelliae Rhizoma Praeparatum,Sichuan Magnoliae Officinalis Cortex,etc.)on gastrointestinal hormones and immunoinflammatory factors in patients with chronic atrophic gastritis(CAG)accompanied by bile reflux.Methods A total of 108 patients with CAG accompanied by bile reflux of insufficiency of stomach yin type,admitted to the Department of Spleen and Stomach Diseases of Shanghai Municipal Hospital of Traditional Chinese Medicine between January 2023 and October 2024,were selected and randomly divided into an observation group and a control group using a random number table method,with 59 patients in each group.The control group received conventional western medicine treatment,while the observation group received Nada Mixture in addition to the conventional treatment for 8 weeks.Changes in gastrointestinal hormones[gastrin-17(G-17),pepsinogen Ⅰ(PGⅠ),pepsinogen Ⅱ(PG Ⅱ)]and immunoinflammatory factors[interleukin-1β(IL-1β),interleukin-8(IL-8),interleukin-10(IL-10)]were observed before and after treatment.Lesion activity,chronic inflammation,and glandular atrophy were evaluated based on endoscopic findings.Clinical efficacy and medication safety were assessed after 8 weeks of treatment.Results(1)Therapeutic effect:After 8 weeks of treatment,the total effective rate was 89.83%(53/59)in the observation group and 74.58%(44/59)in the control group.Intergroup comparison(by chi-square test)showed that the clinical efficacy of the observation group was significantly superior to that of the control group,and the difference was statistically significant(P＜0.05).(2)Gastrointestinal hormones:After treatment,serum levels of G-17,PG Ⅰ,and PG Ⅱ were increased in both groups compared to those before treatment(P＜0.05).Furthermore,the increase was significantly greater in the observation group than in the control group(P＜0.01).(3)Immunoinflammatory factors:After treatment,serum levels of IL-1β and IL-8 were decreased(P＜0.05),while the serum level of IL-10 was increased(P＜0.05)in both groups compared to pre-treatment levels.Moreover,the reductions in IL-1β and IL-8 and the increase in IL-10 were all significantly greater in the observation group than in the control group(P＜0.01).(4)Gastroscopic pathology:At the 6-month follow-up after treatment,the scores for lesion activity,chronic inflammation,and glandular atrophy were all decreased in both groups compared to pre-treatment scores(P＜0.05).The reduction in the chronic inflammation score was significantly greater in the observation group than in the control group(P＜0.01).Although the observation group showed a trend towards greater reductions in lesion activity and glandular atrophy scores compared to the control group,these differences were not statistically significant(P＞0.05).(5)Medication safety:The incidence of adverse reactions was 8.47%(5/59)in the observation group and 16.95%(10/59)in the control group.The intergroup comparison showed no statistically significant difference(P＞0.05).Conclusion Nada Mixture can enhance therapeutic efficacy,improve levels of gastrointestinal hormones and immunoinflammatory factors,and reduce lesion activity,chronic inflammation,and glandular atrophy in patients with CAG accompanied by bile reflux of insufficiency of stomach yin deficiency type,demonstrating safety and effectiveness.关键词
慢性萎缩性胃炎/胆汁反流/纳达合剂/胃阴不足型/胃肠道激素/免疫炎症因子Key words
chronic atrophic gastritis(CAG)/bile reflux/Nada Mixture/insufficiency of stomach yin deficiency type/gastrointestinal hormones/immunoinflammatory factors分类
医药卫生引用本文复制引用
叶悟,王健,孙永顺,汤健,潘相学..纳达合剂对慢性萎缩性胃炎伴胆汁反流患者胃肠道激素及免疫炎症因子的影响[J].广州中医药大学学报,2026,43(2):328-334,7.基金项目
国家自然科学基金资助项目(编号:82174128) （编号:82174128）
