广州医药2026，Vol.57Issue(1)：24-29,6.DOI:10.20223/j.cnki.1000-8535.2026.01.004
中医药调控CD4+T细胞亚群防治动脉粥样硬化的研究进展
Research progress on the regulation of CD4+T cell subsets by traditional Chinese medicine for the prevention and treatment of atherosclerosis
摘要
Abstract
Atherosclerosis(AS)is a chronic vascular disease that originates from inflammation mediated endothelial damage.Its essence is a pathological process driven by immune inflammation,and it is the pathological basis of many cardiovascular diseases.CD4+T cell subsets(including Th1,Th2,Th17,Treg,etc.)participate in the inflammatory response of AS by secreting specific cytokines.The imbalance of anti-inflammatory function between pro-inflammatory CD4+T cells and anti-inflammatory CD4+T cells is a key link in promoting plaque progression and playing a crucial role in the formation and development of AS plaques.In recent years,a number of studies have shown that the monomers,classic prescriptions and their effective ingredients of Chinese herbs have the effect of multi-target,multi-level mechanism to regulate the differentiation and function of CD4+T cells.These effects together reduce the inflammatory reaction of vascular endothelium,inhibit the foam formation of macrophages and smooth muscle cell migration,delay the formation and development of AS plaque,provide new ideas for the prevention and treatment of AS,and make the research of Chinese medicine show unique advantages and broad prospects in this field.This article reviews the latest research progress of Chinese medicine in the prevention and treatment of AS by intervening in the balance of CD4+T cell subsets,as well as the mechanism of its effects on related cytokine networks and key signal pathways.This provides a key theoretical basis and practical direction for the development of innovative traditional Chinese medicine and integrated traditional Chinese and Western medicine treatment plans with multi-target synergistic advantages.关键词
动脉粥样硬化/CD4+T细胞/免疫调节/中医药Key words
atherosclerosis/CD4+T cell/immunoregulation/traditional Chinese medicine引用本文复制引用
叶晨,刘悦,杨欢,盖巧稚,徐月,李珂珂..中医药调控CD4+T细胞亚群防治动脉粥样硬化的研究进展[J].广州医药,2026,57(1):24-29,6.基金项目
国家自然科学基金项目(81703970) （81703970）
辽宁省自然科学基金优秀青年基金计划项目(2023JH3/10200016) （2023JH3/10200016）
