摘要
Abstract
Objective To explore the diagnostic value of clinical features combined with peripheral blood vascular endothelial growth factor(VEGF)and α-hydroxybutyrate dehydrogenase(α-HBDH)levels in ovarian cancer.Methods A total of 84 patients with malignant ovarian cancer admitted to the gynecology department of Tianjin Central Hospital of Gynecology and Obstetrics from June 2022 to June 2024 were included in the observation group,and 84 patients with benign ovarian lesions during the same period were included in the control group.The clinical data and VEGF,α-HBDH levels of the two groups were compared.Pearson analysis was used to explore the correlation between VEGF,α-HBDH levels,and clinical characteristics of patients with malignant ovarian cancer.Binary Logistic regression analysis was conducted to identify independent risk factors for malignant ovarian cancer,and receiver operating characteristic(ROC)curves were used to analyze the diagnostic value of VEGF and α-HBDH levels for malignant ovarian cancer.Results The observation group had significantly higher age,BMI,and serum CA125,HE4,VEGF,α-HBDH levels compared to the control group(P＜0.05).VEGF and α-HBDH levels were significantly positively correlated with FIGO stage,differentiation grade,and lymph node metastasis(P＜0.05).Age,BMI,VEGF,and α-HBDH were included as independent variables in binary Logistic regression,and the results showed that BMI,VEGF,and α-HBDH levels were independent risk factors for malignant ovarian cancer(P＜0.05).ROC curve analysis revealed that the AUC for combined detection of VEGF and α-HBDH reached 0.921,with sensitivity and specificity of 81.0%and 91.7%,respectively,significantly superior to individual detection(VEGF:AUC=0.702;α-HBDH:AUC=0.796).Conclusions The detection of BMI combined with VEGF and α-HBDH levels can provide an efficient and noninvasive auxiliary means for the diagnosis of ovarian cancer,which has important clinical application potential.关键词
临床特征/血管内皮生长因子/α-羟基丁酸脱氢酶/卵巢癌/诊断Key words
clinical features/vascular endothelial growth factor/α-hydroxybutyrate dehydrogenase/ovarian cancer/diagnosis
