四川大学学报（医学版）2026，Vol.57Issue(1)：37-43,7.DOI:10.12182/20260160602
口腔异味的微生物群驱动机制及干预策略的研究进展
Research Progress on Microbiome-Driven Mechanisms and Intervention Strategies for Oral Malodor
摘要
Abstract
Oral malodor,a common oral symptom,is primarily caused by the metabolic activities of oral microorganisms.The characteristic odors mainly originate from volatile sulfur compounds produced and released by oral bacteria(such as Fusobacterium nucleatum and Porphyromonas gingivalis)through specific enzymatic systems that break down sulfur-containing amino acids in saliva,gingival crevicular fluid,and food debris.Research indicates that various factors,including periodontitis,fungal infections,smoking,and obesity,can worsen oral malodor by altering the oral microenvironment.For prevention and treatment,novel interventions such as plant extracts,antimicrobial peptides,and probiotics demonstrate superior microbiological safety compared to traditional antimicrobial drugs.These approaches specifically inhibit pathogenic bacteria,disrupt biofilm structures,and regulate oral microbial balance.This review summarizes relevant research advances to provide new theoretical foundations and practical directions for the precise prevention and treatment of oral malodor.关键词
口腔异味/微生物/挥发性硫化物/牙周病/舌背生物膜/综述Key words
Oral malodor/Microorganisms/Volatile sulfur compounds/Periodontal diseases/Dorsal tongue biofilm/Review引用本文复制引用
尚骁迪,王珍,葛少华..口腔异味的微生物群驱动机制及干预策略的研究进展[J].四川大学学报（医学版）,2026,57(1):37-43,7.基金项目
This work was supported by National Clinical Key Specialty Construction Project(Department of Periodontology,2023). 国家临床重点专科能力建设项目(牙周病科,2023)资助 （Department of Periodontology,2023）
