四川大学学报（医学版）2026，Vol.57Issue(1)：56-64,9.DOI:10.12182/20260160510
衰老背景下口腔微生态失调与功能减退在阿尔茨海默病进程中的作用
Aging-Associated Oral Microbiota Dysbiosis and Hypofunction:Their Role in Alzheimer's Disease Pathogenesis
摘要
Abstract
Alzheimer's disease(AD),a multifactorial neurodegenerative condition,imposes a major burden on societies with aging populations.Recent research indicates that oral cavity health is a critical factor influencing AD pathology,making proactive investigation of this modifiable risk factor essential.This review proposes that aging-related oral microecological dysbiosis and oral hypofunction may promote AD progression by inducing or exacerbating systemic inflammation and disrupting the homeostasis of the"oral-gut-brain"axis.Moreover,each factor may worsen damage through distinct biological pathways:oral microbiota dysbiosis allows direct invasion of the central nervous system by oral pathogens,promoting amyloid β-protein(Aβ)deposition and Tau hyperphosphorylation,while chronic sensory deprivation from oral dysfunction triggers neuronal degeneration and adverse remodeling in key cognitive brain regions.This review aims to systematically elucidate the roles of oral microbiota dysbiosis and oral hypofunction in AD pathogenesis in the context of aging,clarify their underlying biological mechanisms,and explore the potential value of integrating oral cavity health management into comprehensive AD prevention and treatment strategies.关键词
阿尔茨海默病/衰老/口腔/生态失调/综述Key words
Alzheimer's disease/Aging/Oral cavity/Dysbiosis/Review引用本文复制引用
李雅卓,陈雨晴,陈帅,黄晓晶..衰老背景下口腔微生态失调与功能减退在阿尔茨海默病进程中的作用[J].四川大学学报（医学版）,2026,57(1):56-64,9.基金项目
This work was supported by the Health and Medical Science and Technology Project of Fujian Province(No.2022GGA042). 福建省卫生健康科技计划项目(No.2022GGA042)资助 （No.2022GGA042）
