四川大学学报（医学版）2026，Vol.57Issue(1)：217-223,7.DOI:10.12182/20260160603
半乳糖凝集素-9和音猬因子表达检测在结直肠癌早期诊断及预后中的作用
Role of Galectin-9 and Sonic Hedgehog Expressions in the Early Diagnosis and Prognosis of Colorectal Cancer
摘要
Abstract
Objective To investigate the association between the expression levels of galectin-9 and sonic hedgehog(SHH)and the risk of occurrence and prognosis in patients with colorectal cancer(CRC).Methods A total of 210 patients with CRC treated at Qingdao Traditional Chinese Medicine Hospital between May 2020 and May 2022 were retrospectively included.The expressions of galectin-9 and SHH in tumor tissues were measured.Logistic regression was used to analyze the relationship between galectin-9/SHH expression and CRC risk.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of galectin-9 and SHH for CRC risk and prognosis.Results The expression levels of galectin-9 and SHH differed significantly between cancer tissues and adjacent normal tissues(P<0.05).ROC analysis showed that the AUCs for galectin-9 and SHH in evaluating CRC risk were 0.809(95%CI:0.751-0.868)and 0.865(95%CI:0.817-0.912),respectively.Galectin-9 expression was lower in patients with T3-4 stage,N1-3 stage,M1 stage,or poor differentiation(P<0.05),whereas SHH expression was higher in these patients(P<0.05).Galectin-9 expression was negatively correlated with SHH expression and TNM stage(r=-0.184 and-0.362,respectively;P<0.001).SHH expression was positively correlated with TNM stage(r=0.407,P<0.001).Significant differences in galectin-9 and SHH expression were observed between patients with poor prognosis and those with good prognosis(P<0.05).Logistic regression analysis indicated that T3-4 stage(OR=4.609,95%CI:1.461-14.535),poor differentiation(OR=3.337,95%CI:1.297-8.582),and high SHH expression(OR=2.067,95%CI:1.162-3.678)were risk factors for poor prognosis(P<0.05),while high galectin-9 expression(OR=0.652,95%CI:0.437-0.975)was a protective factor(P<0.05).The AUCs of galectin-9 and SHH for evaluating CRC prognosis were 0.769(95%CI:0.550-0.798)and 0.734(95%CI:0.603-0.866),respectively.Conclusion Galectin-9 and SHH are lowly and highly expressed,respectively,in CRC.Their expression levels are associated with tumor differentiation,invasion,and metastasis,and hold predictive value for the risk and prognosis of CRC patients.关键词
结直肠癌/半乳糖凝集素-9/音猬因子/预后/预测价值Key words
Colorectal cancer/Galectin-9/Sonic hedgehog/Prognosis/Predictive value引用本文复制引用
何倩,刘昕,林甜甜,董笑楠..半乳糖凝集素-9和音猬因子表达检测在结直肠癌早期诊断及预后中的作用[J].四川大学学报（医学版）,2026,57(1):217-223,7.基金项目
This study was supported by 2022 Shandong Provincial Traditional Chinese Medicine Science and Technology Project(No.Q-2022009). 2022年度山东省中医药科技项目(No.Q-2022009) （No.Q-2022009）
