军事医学2026，Vol.50Issue(1)：58-63,6.DOI:10.7644/j.issn.1674-9960.2025-00128
大麻二酚与抑郁症治疗:基于血脑屏障损伤修复的前沿机制探索
Cannabidiol and treatment of depression:an exploration of cutting-edge mechanisms based on blood-brain barrier repair
摘要
Abstract
Depression is a common mental disorder,the pathogenesis of which involves such factors as the imbalance of the monoamine system,neuroinflammation,and oxidative stress.Depression has been found to be associated with dysfunction in the blood-brain barrier(BBB).In recent years,cannabidiol(CBD)has attracted extensive attention due to its remarkable antidepressant activity and neuroprotective properties.Of particular interest is the possibility that CBD may combat depression by repairing BBB damage and thereby improving the homeostasis of the central nervous system.Based on recent research findings,this article explores the antidepressant mechanisms of CBD,the BBB damage in depression,and the protective effects of CBD on the BBB.It is expected to provide references for subsequent studies on the mechanisms of BBB damage in depression and the discovery of new antidepressant targets.关键词
大麻二酚/抑郁症/血脑屏障/紧密连接蛋白/神经炎症Key words
cannabidiol/depression/blood-brain barrier/tight junction proteins/neuroinflammation分类
医药卫生引用本文复制引用
陈悦,龙倩,江小霞,麻慧,乔鑫..大麻二酚与抑郁症治疗:基于血脑屏障损伤修复的前沿机制探索[J].军事医学,2026,50(1):58-63,6.基金项目
北京市自然科学基金项目(7232348) （7232348）
国家自然科学基金项目(82204360) （82204360）
