军事医学2026，Vol.50Issue(1)：70-77,8.DOI:10.7644/j.issn.1674-9960.2025-00108
乳腺癌软脑膜转移的诊断及治疗进展
Advances in diagnosis and treatment of leptomeningeal metastases from breast cancer
董晓培 1张少华2
作者信息
- 1. 解放军总医院肿瘤医学部,北京 100071
- 2. 解放军总医院肿瘤医学部,北京 100071||安徽医科大学,合肥 230031
- 折叠
摘要
Abstract
Leptomeningeal metastases(LM)in breast cancer patients are rare,but are usually accompanied by severe symptoms and a very poor prognosis.So far,MRI of the brain and/or spinal cord and cytological examination of cerebrospinal fluid(CSF)are the two primary methods used to diagnose LM.However,the sensitivity of either technique is limited,leading to a long diagnostic process,and delaying treatment.Traditional chemotherapy and targeted therapies used to treat systemic diseases are hampered by the blood-brain barrier.Similarly,the efficacy of intrathecal therapy and radiotherapy is controversial.This review summarized advances in the diagnosis and therapies of LM in breast cancer,in the hopes of providing a reference for clinical practice.关键词
乳腺肿瘤/软脑膜转移/诊断/治疗进展Key words
breast neoplasms/leptomeningeal metastases/diagnosis/therapeutic progress分类
医药卫生引用本文复制引用
董晓培,张少华..乳腺癌软脑膜转移的诊断及治疗进展[J].军事医学,2026,50(1):70-77,8.
