结核与肺部疾病杂志2026，Vol.7Issue(1)：21-29,9.DOI:10.19983/j.issn.2096-8493.20250091
中国结核分枝杆菌潜伏感染预防性治疗接受度及影响因素Meta分析
Acceptance of preventive treatment for latent tuberculosis infection and its influencing factors:a Meta-analysis
摘要
Abstract
Objective:To systematically evaluate the acceptance rate of preventive treatment and its influencing factors among individuals with latent tuberculosis infection(LTBI)in China,and to provide evidence for public health departments to implement targeted LTBI interventions.Methods:Chinese and English databases(including CNKI,Wanfang,VIP,CBM,PubMed,Web of Science,Embase,and The Cochrane Library)were searched for studies published up to February 19,2025,related to preventive treatment for LTBI in China.Two researchers independently screened literature,extracted data,and assessed study quality.Stata 14.0 was used for Meta-analysis to calculate the pooled acceptance rate and analyze influencing factors.Results:A total of 16 studies were included,involving 8806 participants.The pooled acceptance rate of preventive treatment among LTBI individuals in China was 66.2％(95％CI:56.9％—74.9％).Subgroup analysis showed higher acceptance rates in western regions(70.0％)and in studies published before 2020(68.7％).Demographic analysis revealed higher acceptance among females(68.4％),individuals aged 18-45 years(80.1％),and those with education levels of junior high school or below(77.7％).Acceptance was highest among close contacts of pulmonary tuberculosis patients(79.5％),followed by other high-risk populations(71.9％),and lowest among students identified with LTBI through school screening(51.4％).Multivariable analysis identified the following protective factors:females(OR=1.05,95％CI:1.01-1.16),being a student(OR=1.23,95％CI:1.04-1.52)or manual laborers(OR=1.65,95％CI:1.39-1.93),having good knowledge of the disease(OR=1.18,95％CI:1.07-1.29),and a history of BCG vaccination(OR=1.42,95％CI:1.01-2.08).Risk factors included being boarding students(OR=0.61,95％CI:0.35-0.88)and longer treatment regimens(OR=0.38,95％CI:0.04-0.71).Conclusion:The acceptance rate of preventive treatment among individuals with LTBI in China remains suboptimal.Strengthening health education,addressing stigma,improving disease awareness,and promoting shorter treatment regimens may help enhance treatment uptake in key populations.关键词
结核/分枝杆菌感染/预防医学/病人接受卫生保健的程度/系统分析Key words
Tuberculosis/Mycobacterium infections/Preventive medicine/Patient acceptance of health care/Systems analysis分类
医药卫生引用本文复制引用
杨宇兰,万彬,赵霞,沈靖,姚蓉,余巧林,何婷..中国结核分枝杆菌潜伏感染预防性治疗接受度及影响因素Meta分析[J].结核与肺部疾病杂志,2026,7(1):21-29,9.基金项目
四川省医学会医学科研项目(S2024036) （S2024036）
四川省卫生健康委员会科技项目(24QNMP049) Medical Research Project of Sichuan Medical Association(S2024036) （24QNMP049）
Science and Technology Project of the Sichuan Provincial Institute Health Center Commission(24QNMP049) （24QNMP049）
