华东理工大学学报（自然科学版）2026，Vol.52Issue(1)：83-89,7.DOI:10.14135/j.cnki.1006-3080.20250327001
羟丙基-β-环糊精对阿魏酸-烟酰胺共晶的包合作用及溶液性质研究
Inclusion Effect and Solution Properties of Hydroxypropyl-β-Cyclodextrin on Ferulic-Nicotinamide Cocrystal
摘要
Abstract
To investigate the effect of the inclusion interaction of cyclodextrin-based materials on the properties of plant active substances,ferulic acid-nicotinamide cocrystal(FA-NIC)/hydroxypropyl-β-cyclodextrin(HP-β-CD)inclusion complexes were prepared.The inclusion behavior of HP-β-CD towards FA-NIC cocrystals and the solution properties were studied.Phase solubility curves and Job's plots indicated that FA-NIC cocrystals form inclusion complexes with HP-β-CD at a molar ratio of 1∶1.Results from X-ray diffraction(XRD)and Fourier transform infrared(FT-IR)spectroscopy demonstrated that hydrogen bonding interactions exist between the FA-NIC cocrystals encapsulated in the hydrophobic cavity of HP-β-CD and the hydroxyl groups of HP-β-CD.Due to the hydrophobic interactions between the C-H bonds and glycosidic bonds in the hydrophobic cavity of HP-β-CD and FA-NIC cocrystals,FA exhibited enhanced ultraviolet(UV)absorption and fluorescence intensity.Compared with pure FA,the equilibrium solubility in water,UV light stability,and DPPH(1,1-diphenyl-2-picrylhydrazyl)free radical scavenging rate of FA in the FA-NIC/HP-β-CD inclusion complex were increased by 5.7-fold,17.9 percentage points,and approximately 1-fold,respectively.关键词
阿魏酸/共晶/环糊精/包合作用/溶液Key words
ferulic acid/cocrystal/cyclodextrin/inclusion effect/solution分类
化学化工引用本文复制引用
井艺霏,王小永,宁德勇,马晓烨,宋轲薪,黄子昊..羟丙基-β-环糊精对阿魏酸-烟酰胺共晶的包合作用及溶液性质研究[J].华东理工大学学报（自然科学版）,2026,52(1):83-89,7.基金项目
国家自然科学基金(22273022) （22273022）
