解放军医学院学报2025，Vol.46Issue(11)：1090-1094,1102,6.DOI:10.12435/j.issn.2095-5227.25083001
干细胞来源外泌体治疗椎间盘退变的研究进展
Research advances in stem cell exosomes in treatment of intervertebral disc degeneration
摘要
Abstract
Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nm,carrying abundant bioactive substances such as nucleic acids,proteins,and lipids.They play a crucial role in intercellular communication and material exchange.In vitro and in vivo studies indicate that stem cell-derived exosomes can delay intervertebral disc degeneration through a triple mechanism:regulating molecules centered on microRNA,inhibiting apoptosis,reducing inflammatory factor expression,and maintaining extracellular matrix homeostasis.This paper systematically reviews the research progress on stem cell-derived exosomes in the treatment of intervertebral disc degeneration in recent years,deeply analyzes their mechanisms of action,and discusses the current challenges faced by the field as well as future development directions.关键词
干细胞/外泌体/椎间盘退变/细胞凋亡/炎症/细胞外基质Key words
stem cell/exosomes/intervertebral disc degeneration/apoptosis/inflammation/extracellular matrix分类
医药卫生引用本文复制引用
侯佩宏,崔钰惠,胡文浩,张雪松..干细胞来源外泌体治疗椎间盘退变的研究进展[J].解放军医学院学报,2025,46(11):1090-1094,1102,6.基金项目
北京市自然科学基金项目(7232167) （7232167）
