解放军医学院学报2025，Vol.46Issue(11)：1110-1114,封3,6.DOI:10.12435/j.issn.2095-5227.25032302
孕期应激对子代呼吸系统影响的研究进展
Research advances in impact of prenatal stress on offspring respiratory system
摘要
Abstract
Prenatal stress(PS),as an important form of intrauterine adversity,has drawn growing attention for its long-term impacts on offspring health.In recent years,extensive studies have revealed that PS disrupts offspring development,particularly showing a close association with increased risks of diseases such as asthma.However,the precise underlying mechanisms remain poorly understood.Therefore,this paper focuses on the effects of prenatal stress on the structure and function of the respiratory system in offspring,systematically reviewing potential mechanisms including hypothalamic-pituitary-adrenal(HPA)axis activation,immune dysregulation,abnormal Wnt signaling pathway,and epigenetic modifications,while exploring their interactions,with the aim of providing a theoretical basis for early intervention.关键词
孕期应激/呼吸系统疾病/下丘脑-垂体-肾上腺轴/表观遗传学/线粒体功能障碍Key words
prenatal stress/respiratory system diseases/hypothalamic-pituitary-adrenal axis/epigenetics/mitochondrial dysfunction分类
医药卫生引用本文复制引用
孙绪琪,吴伟,徐若飞,赵坤宇,杨甲辰,姚雪萍..孕期应激对子代呼吸系统影响的研究进展[J].解放军医学院学报,2025,46(11):1110-1114,封3,6.基金项目
国家自然科学基金(82160218) （82160218）
新疆医科大学大学生创新训练项目(S202310760015) （S202310760015）
