检验医学与临床2026，Vol.23Issue(3)：333-337,344,6.DOI:10.3969/j.issn.1672-9455.2026.03.008
ERCP+EST与ESPBD治疗肝硬化合并胆总管结石的临床对照研究
Clinical comparative study of ERCP+EST versus ESPBD in the treatment of patients with liver cirrhosis and common bile duct stones
摘要
Abstract
Objective To investigate the clinical efficacy of endoscopic retrograde cholangiopancreatogra-phy(ERCP)+endoscopic sphincterotomy(EST)and endoscopic sphincterotomy combined with balloon dila-tion(ESPBD)in the treatment of patients with liver cirrhosis(LC)complicated with common bile duct stones(CBDS).Methods A total of 167 patients with LC combined with CBDS admitted to the Third People's Hos-pital of Hengshui from January 2021 to June 2024 were selected as the research objects.According to different surgical methods,they were divided into EST group(treated with ERCP+EST,85 cases)and ESPBD group(treated with ESPBD,82 cases).The perioperative indicators(operation time,intraoperative blood loss,anal exhaust time,hospitalization time and one-time stone clearance rate),liver function indicators[aspartate amin-otransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL)],inflammatory factors[inter-leukin-6(IL-6),C-reactive protein(CRP)]and complications were compared between the two groups.Results The one-time stone clearance rate of ESPBD group was higher than that of EST group(P<0.05).The levels of AST,ALT and TBIL in the two groups after operation were lower than those before operation,and the differences were statistically significant(P<0.05).The levels of IL-6 and CRP in the two groups af-ter operation were lower than those before operation,and the levels of IL-6 and CRP in the ESPBD group were lower than those in the EST group,and the differences were statistically significant(P<0.05).The incidence of complications in the ESPBD group was lower than that in the EST group(P<0.05).Conclusion ERCP combined with EST and ESPBD can effectively improve the perioperative indicators and liver function of pa-tients,and ESPBD can better reduce the level of inflammation and reduce the incidence of complications.关键词
肝硬化/胆总管结石/内镜下逆行胰胆管造影/十二指肠乳头括约肌切开术/内镜下十二指肠乳头括约肌小切开联合球囊扩张术/临床疗效Key words
liver cirrhosis/common bile duct stone/endoscopic retrograde cholangiopancreatography/endoscopic sphincterotomy/endoscopic sphincterotomy combined with balloon dilation/clinical efficacy分类
医药卫生引用本文复制引用
何国维,张世喆,彭志敏,孙梅兰,沈晓旭,刘学敏,黄林凤,王广海..ERCP+EST与ESPBD治疗肝硬化合并胆总管结石的临床对照研究[J].检验医学与临床,2026,23(3):333-337,344,6.基金项目
河北省卫生健康委员会医学科学研究课题计划项目(20251592). （20251592）
