检验医学与临床2026，Vol.23Issue(3)：366-370,5.DOI:10.3969/j.issn.1672-9455.2026.03.013
血清CA50、CA-242水平与结直肠癌患者发生淋巴结转移的关系
Serum CA50 and CA-242 levels and the relationship with lymph node metastasis in patients with colorectal cancer
摘要
Abstract
Objective To explore the relationship between serum carbohydrate antigen(CA50)and carbo-hydrate antigen 242(CA-242)levels and lymph node metastasis in patients with colorectal cancer(CRC).Methods A total of 160 CRC patients admitted to the hospital from July 2022 to July 2024 were selected as the research subjects.They were divided into the lymph node metastasis group(72 cases)and the lymph node non-metastasis group(88 cases)based on whether lymph node metastasis occurred.The serum CA50 and CA-242 levels of the patients were detected by enzyme-linked immunosorbent assay.Multivariable Logistic regres-sion analysis was used to analyze the influencing factors of lymph node metastasis in CRC patients.The diag-nostic value of serum CA50 and CA-242 for lymph node metastasis in CRC patients was analyzed by drawing the receiver operating characteristic(ROC)curve.Results The proportions of patients with TNM stage Ⅲ-Ⅳ,poorly differentiated tumors,and tumor maximum diameter≥4.0 cm and the serum CA50 and CA-242 levels in the lymph node metastasis group were higher than those in the lymph node non-metastasis group,with statistically significant differences(P<0.05).The serum CA50 and CA-242 levels were higher in pa-tients with TNM stage Ⅲ-Ⅳ and poorly differentiated tumors than in those with TNM stage Ⅰ-Ⅱ and mod-erately to highly differentiated tumors,with statistically significant differences(P<0.05).The results of multivariable Logistic regression analysis showed that elevated serum CA50 and CA-242 levels were risk fac-tors for lymph node metastasis in CRC patients(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of the combined diagnosis of the two indicators for lymph node metastasis in CRC patients was 0.931,which was larger than the AUC of CA50 and CA-242 alone(Z=3.489,2.951,both P<0.05).Conclusion The serum CA50 and CA-242 levels are elevated in CRC patients with lymph node metastasis,and the combination of serum CA50 and CA-242 can be used as a biomarker for diagnosing lymph node metastasis in CRC patients.关键词
碳水化合物抗原/糖类抗原242/结直肠癌/淋巴结转移Key words
carbohydrate antigen/carbohydrate antigen 242/colorectal cancer/lymph node分类
医药卫生引用本文复制引用
黄炳红,邵远江,邵宏娅,庄小军..血清CA50、CA-242水平与结直肠癌患者发生淋巴结转移的关系[J].检验医学与临床,2026,23(3):366-370,5.基金项目
四川省医学科研课题计划项目(S23WS1030). （S23WS1030）
