检验医学与临床2026，Vol.23Issue(3)：421-427,7.DOI:10.3969/j.issn.1672-9455.2026.03.022
动脉粥样硬化的细胞靶向治疗策略研究进展
Research progress on cellular targeted therapy strategies for atherosclerosis
摘要
Abstract
Atherosclerosis is a chronic vascular disease driven by both lipid metabolism disorders and chro-nic inflammation,and it remains a leading cause of cardiovascular and cerebrovascular events.This review fo-cuses on the cellular mechanisms involved in the pathogenesis and progression of atherosclerosis,with particu-lar emphasis on macrophages,vascular endothelial cells and vascular smooth muscle cells,as well as recent ad-vances in targeting these cells for therapeutic purposes.As key immune cells,macrophages are central to lipid uptake,inflammatory cytokine release,and necrotic core formation,making them a hotspot in current cell-tar-geted therapy research.Endothelial dysfunction initiates lesion development,and strategies that preserve or re-store endothelial function are crucial for disease attenuation.Vascular smooth muscle cells contribute to both fibrous cap formation and plaque stability,and their phenotypic switching is closely associated with plaque vul-nerability.In recent years,a variety of targeted intervention strategies have emerged based on these cells,in-cluding small-molecule drugs,RNA interference technologies,and nanoparticle-based delivery systems,all demonstrating significant research value and clinical potential.However,challenges such as low delivery effi-ciency,limited specificity,and translational barriers remain.Future research should emphasize the intercellular mechanisms involved in atherosclerosis,optimize delivery platforms,and explore multi-target combinatorial strategies to provide a more robust theoretical and technological foundation for the precise prevention and treatment of atherosclerosis.关键词
动脉粥样硬化/巨噬细胞/血管内皮细胞/血管平滑肌细胞/靶向治疗Key words
atherosclerosis/macrophages/vascular endothelial cell/vascular smooth muscle cell/targeted therapy分类
医药卫生引用本文复制引用
蒋如芳,文雯,刘健..动脉粥样硬化的细胞靶向治疗策略研究进展[J].检验医学与临床,2026,23(3):421-427,7.基金项目
国家自然科学基金项目(No.81800446) （No.81800446）
四川省医学会科研项目(S22050) （S22050）
四川省教育厅科研项目(JG2021-1205) （JG2021-1205）
成都医学院第一附属医院科研项目(CYFY-GQ18). （CYFY-GQ18）
