临床肝胆病杂志2026，Vol.42Issue(1)：178-182,5.DOI:10.12449/JCH260122
阿司匹林在代谢相关脂肪性肝病中的作用
Role of aspirin in metabolic associated fatty liver disease
摘要
Abstract
Metabolic associated fatty liver disease(MAFLD)is the main type of chronic liver disease in the world,with an increasingly higher incidence rate and a younger age of onset.At present,the treatment of MAFLD mainly depends on lifestyle intervention and comorbidity management,and there is still a lack of effective drugs for MAFLD itself.As a classic nonsteroidal anti-inflammatory drug of the salicylic acid family,aspirin can intervene in the pathological process of MAFLD by regulating lipid metabolism,relieving insulin resistance,reducing liver inflammation and oxidative stress response,exerting an anti-liver fibrosis effect,and inhibiting hepatocellular carcinoma,and therefore,it has the value of preventing disease onset,delaying disease progression,and reversing disease condition.This article systematically reviews the mechanism of action and safety of aspirin in the treatment of MAFLD,in order to provide more drug treatment options for MAFLD patients.关键词
代谢相关脂肪性肝病/阿司匹林/药物疗法Key words
Metabolic Associated Fatty Liver Disease/Aspirin/Drug Therapy引用本文复制引用
李永琪,李妍秋,孙丽娜,王超冉,冯颖,王亮,王宪波..阿司匹林在代谢相关脂肪性肝病中的作用[J].临床肝胆病杂志,2026,42(1):178-182,5.基金项目
国家自然科学基金(82474419) （82474419）
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023005) （zyyzdxk-2023005）
首都卫生发展科研专项(2024-1-2173) National Natural Science Foundation of China(82474419) （2024-1-2173）
National Administration of Traditional Chinese Medicine High Level Key Discipline Construction Project of Traditional Chinese Medicine(zyyzdxk-2023005) （zyyzdxk-2023005）
Capital's Funds for Health Improvement and Research(2024-1-2173) （2024-1-2173）
