临床肝胆病杂志2026，Vol.42Issue(1)：197-202,6.DOI:10.12449/JCH260125
细胞焦亡在肝纤维化中的作用及研究进展
Role of pyroptosis in hepatic fibrosis and related research advances
摘要
Abstract
Hepatic fibrosis is not only a pathological process of hepatic self-repair after chronic liver injury,but also a critical stage in the progression of chronic liver disease to liver cirrhosis.Studies have shown that as a pro-inflammatory form of programmed cell death,pyroptosis plays an important role in various diseases and is also considered a potential therapeutic target for hepatic fibrosis.This article systematically reviews the association of pyroptosis in hepatocytes,hepatic stellate cells,and hepatic macrophages with hepatic fibrosis and discusses pyroptosis-mediated therapeutic strategies targeting hepatic fibrosis.关键词
细胞焦亡/肝纤维化/炎症小体Key words
Pyroptosis/Hepatic Fibrosis/Inflammasome引用本文复制引用
金泳帆,赵春梅,邰文琳..细胞焦亡在肝纤维化中的作用及研究进展[J].临床肝胆病杂志,2026,42(1):197-202,6.基金项目
国家自然科学基金(82060385) National Natural Science Foundation of China(82060385) （82060385）
