临床肝胆病杂志2026，Vol.42Issue(1)：217-221,5.DOI:10.12449/JCH260128
甲状腺功能异常相关肝损伤的研究进展
Research advances in liver injury associated with thyroid dysfunction
摘要
Abstract
The thyroid gland is the largest endocrine organ in the human body,and its dysfunction can cause varying degrees of liver injury,leading to liver failure in severe cases.Patients with hyperthyroidism have a relatively high incidence rate of liver dysfunction,manifesting as hepatocellular injury or cholestatic liver injury,while hypothyroidism is closely associated with metabolic dysfunction-associated fatty liver disease.Autoimmune thyroid diseases,including Hashimoto's thyroiditis and subacute thyroiditis,are commonly comorbid with autoimmune liver disease.In addition,medications such as antithyroid drugs,amiodarone,and immune checkpoint inhibitors can cause severe liver injury through direct toxicity or immune-mediated mechanisms.Although significant progress has been achieved in related diagnosis and treatment techniques in recent years,there are still many challenges in pathogenesis,individualized treatment strategies,early warning,and prognostic evaluation.This article systematically reviews the research advances in liver injury associated with thyroid dysfunction and proposes the directions for future research,in order to provide guidance for clinical diagnosis and treatment.关键词
甲状腺功能亢进症/甲状腺功能减退症/肝损伤/治疗学Key words
Hyperthyroidism/Hypothyroidism/Liver Injury/Therapeutics引用本文复制引用
刘叶,吴晶燕,钟沁洋,李武..甲状腺功能异常相关肝损伤的研究进展[J].临床肝胆病杂志,2026,42(1):217-221,5.基金项目
国家自然科学基金(82160801) （82160801）
云南省"万人计划"名医专项(YNWR-MY-2020-018) National Natural Science Foundation of China(82160801) （YNWR-MY-2020-018）
Yunnan Province"Ten Thousand Talents Program"Distinguished Physician Project(YNWR-MY-2020-018) （YNWR-MY-2020-018）
