辽宁中医药大学学报2026，Vol.28Issue(2)：154-158,5.DOI:10.13194/j.issn.1673-842X.2026.02.026
银杏酮酯片干预乳腺癌化疗相关认知障碍前瞻性队列研究
A Prospective Cohort Study of Effect of Ginkgo Ketone Ester Tablets on Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients
摘要
Abstract
Objective This prospective cohort study conducted a 24-week clinical follow-up on patients previously treated with anthracycline-based or sequential paclitaxel-containing chemotherapy regimens to evaluate the effects of Ginkgo Ketone Ester Tablets on chemotherapy-related cognitive impairment(CRCI),somatization disorders,and quality of life scores in breast cancer patients.Serum biomarkers were analyzed to explore potential mechanisms.Methods From January 2022 to September 2023,96 female breast cancer patients scheduled for or undergoing chemotherapy at the integrated breast oncology department of Longhua hospital,Shanghai university of traditional Chinese medicine were enrolled.Using a prospective cohort design,participants were divided into an exposed group(Ginkgo Ketone Ester Tablets+adjuvant chemotherapy)and a non-exposed group(adjuvant chemotherapy alone),with 24-week follow-up.Primary outcomes included Memory and Executive Screening(MES)scale and event-related potential P300 parameters.Secondary outcomes encompassed Traditional Chinese Medicine(TCM)symptom scale,serum oxidative stress markers,and safety profiles.Results At 24-week follow-up,the exposed group demonstrated significantly lower incidence of CRCI and superior TCM symptom alleviation across all domains compared to controls(P<0.05).No significant intergroup differences were observed in P300 parameters(Cz/Pz latency and amplitude,P>0.05).Serum analysis revealed Ginkgo Ketone Ester Tablets significantly elevated GSH levels and reduced ROS(P<0.05),while TNF-α reduction was non-significant(P>0.05).No adverse events occurred during follow-up.Conclusion Ginkgo Ketone Ester Tablets improved memory,attention,executive function,and learning ability in breast cancer patients with CRCI,while alleviating psychological,somatic,and functional status,thereby reducing the adverse impact of CRCI on patients'quality of life.The therapeutic mechanism may involve elevating serum GSH levels and suppressing ROS,collectively mitigating neural oxidative damage.Further animal studies are warranted to elucidate the precise efficacy and molecular pathways underlying Ginkgo Ketone Ester Tablets in CRCI management.关键词
银杏酮酯/乳腺癌/化疗相关认知障碍/生活质量/氧化应激Key words
ginkgo ketone ester/breast cancer/chemotherapy-related cognitive impairment/quality of life/oxidative stress分类
医药卫生引用本文复制引用
陈佳静,陈力新,蒋可心,吴春宇,刘胜,秦悦农,孙霃平,宋晓耘..银杏酮酯片干预乳腺癌化疗相关认知障碍前瞻性队列研究[J].辽宁中医药大学学报,2026,28(2):154-158,5.基金项目
国家自然科学基金面上项目(82474508) （82474508）
上海市2023年度"科技创新行动计划"科技成果转化服务体系建设项目(23Y11920700) （23Y11920700）
