国际眼科杂志2026，Vol.26Issue(3)：368-374,7.DOI:10.3980/j.issn.1672-5123.2026.3.02
多发性硬化症患者视网膜层厚度及血管参数研究
Retinal layers thickness and retinal vascular parameters in patients with multiple sclerosis
Mehdi Moghaddasi 1Mahsa Sardarinia 2Mostafa Soltansanjari 2Ahmad Vafajoo 1Nafise Mohebi 1Simin Zare1
作者信息
- 1. (1449614535)伊朗德黑兰,伊朗医科大学 Rassoul Akram医院神经内科
- 2. (1449614535)伊朗德黑兰,伊朗医科大学五官健康研究所眼科研究中心
- 折叠
摘要
Abstract
•AIM:To investigate the changes of retinal vascular parameters and retinal layer thickness in patients with multiple sclerosis(MS).
•METHODS:This single-centered case-control study was performed on a MS group of 42 patients diagnosed with MS and a control group of 43 healthy hospital staff matched in terms of age and sex at Iran University,department of neurology and ophthalmology from March 2020 to March 2021.The ophthalmic parameters of each patient were recorded,and optical coherence tomography was used to evaluate the retinal thickness in the layers.
•RESULTS:This study enrolled a total of 85 participants,with a mean age of 40.44±11.52 years,including 61 females(72%).The control group consisted of 43 individuals with a mean age of 39.49±11.07 years,while the MS group comprised 42 participants with a mean age of 41.40±12.01 years.The mean disease duration in the MS group was 8.45±6.04 a.The thickness of the ganglion cell layer in the right eye was significantly lower in the MS group compared to the control group(P=0.034).In addition,except for the left nasal sector(P=0.106),the mean peripapillary neurofibrillation in all examined sectors were significantly lower in the MS group than in the control group(P<0.05).The average vessel density in both the deep and superficial capillary plexuses across all regions of both eyes was lower in the MS group than in the control group,with all comparisons for the superficial capillary plexus showing statistical significance(P<0.05 for all except the left nasal sector).
•CONCLUSION:The thickness of the retina of patients with MS is significantly reduced.Therefore,optical coherence tomography results can be used as a reliable tool to evaluate disease progression and prognosis in MS patients.关键词
多发性硬化症/光学相干断层扫描/视网膜/视网膜血管性疾病/视网膜层厚度Key words
multiple sclerosis/optical coherence tomography/retina/retinal vascular disorder/retinal layer thickness引用本文复制引用
Mehdi Moghaddasi,Mahsa Sardarinia,Mostafa Soltansanjari,Ahmad Vafajoo,Nafise Mohebi,Simin Zare..多发性硬化症患者视网膜层厚度及血管参数研究[J].国际眼科杂志,2026,26(3):368-374,7.
