国际眼科杂志2026，Vol.26Issue(3)：410-416,7.DOI:10.3980/j.issn.1672-5123.2026.3.08
线粒体相关内质网膜在致盲性眼病发病机制中的研究现状
Research status of mitochondria-associated endoplasmic reticulum membranes in the pathogenesis of blinding ocular diseases
摘要
Abstract
Mitochondria-associated endoplasmic reticulum membranes(MAMs)are crucial structural links between the endoplasmic reticulum and mitochondria,formed by a complex protein network.They play a central role in cellular calcium signaling homeostasis,mitochondrial stability,endoplasmic reticulum stress,and inflammatory response.In recent years,advances in subcellular ultrastructure research techniques have gradually uncovered the relationship between MAMs dysfunction and blinding ocular diseases.Studies indicate that structural or functional impairments in MAMs can disrupt retinal pigment epithelial cells homeostasis,compromise the survival microenvironment of retinal ganglion cells,and trigger corneal endothelial cells apoptosis,thereby contributing to the pathogenesis of various blinding ocular diseases including age-related macular degeneration,diabetic retinopathy,Fuchs endothelial corneal dystrophy,and glaucoma.This article reviews the molecular mechanisms linking MAMs in common blinding ocular diseases.关键词
线粒体相关内质网膜/致盲性眼病/线粒体功能障碍/内质网应激/免疫炎症反应Key words
mitochondria-associated endoplasmic reticulum membranes/blinding ocular diseases/mitochondrial dysfunction/endoplasmic reticulum stress/inflammatory response引用本文复制引用
周柯汶,刘庆平,张铭志..线粒体相关内质网膜在致盲性眼病发病机制中的研究现状[J].国际眼科杂志,2026,26(3):410-416,7.基金项目
国家自然科学基金项目(No.82171044) （No.82171044）
广东省科技专项资金项目(No.2019ST024) （No.2019ST024）
广东省普通高校重点科研平台和项目(No.2022LSYS006,2023KCXTD013) National Natural Science Foundation of China(No.82171044) （No.2022LSYS006,2023KCXTD013）
Special Fund for Science and Technology of Guangdong Province(No.2019ST024) （No.2019ST024）
the Key Research Platforms and Projects of Guangdong Provincial Universities(No.2022LSYS006,2023KCXTD013) （No.2022LSYS006,2023KCXTD013）
