国际眼科杂志2026，Vol.26Issue(3)：493-498,6.DOI:10.3980/j.issn.1672-5123.2026.3.23
房水SDF-1与ENA78水平对DR患者玻璃体切割术后视力残疾的预测价值
Predictive value of aqueous humor stromal cell-derived factor-1 and epithelial neutrophil-activating peptide-78 levels for visual impairment following vitrectomy in patients with diabetic retinopathy
摘要
Abstract
•AIM:To investigate the predictive value of aqueous humor stromal cell-derived factor-1(SDF-1)and epithelial neutrophil-activating peptide-78(ENA78)for visual impairment following vitrectomy in patients with diabetic retinopathy(DR). •METHODS:Patients with DR who underwent vitrectomy in the ophthalmology department of our hospital from March 2022 to March 2024 were enrolled as study group.According to the results of uncorrected visual acuity examination during the 1-year follow-up after surgery,they were further divided into visual impairment group and good visual acuity group.In addition,patients with cataracts who were treated in our hospital during the same period were recruited as control group.The levels of SDF-1 and ENA78 in aqueous humor were detected by enzyme-linked immunosorbent assay(ELISA).Pearson correlation analysis was used to evaluate the correlation of indicators.Multivariate Logistic regression analysis was performed to identify the influencing factors of postoperative visual impairment in DR patients.Relative risk analysis was conducted to assess the impact of different aqueous humor SDF-1 and ENA78 levels on postoperative visual impairment in DR patients.Receiver operating characteristic(ROC)curve analysis was applied to determine the predictive value of aqueous humor SDF-1 and ENA78 levels for postoperative visual impairment in DR patients. •RESULTS:Totally 156 cases(156 eyes)were enrolled in the study group,including 87 males and 69 females,with a mean age of 60.65±8.91 years old;and 91 cases(91 eyes)were enrolled in the control group,including 53 males and 38 females,with a mean age of 58.72±8.43 years old.The levels of SDF-1 and ENA78 in aqueous humor of the study group were significantly higher than those of the control group(P<0.001).According to the results of uncorrected visual acuity during the 1-year follow-up after surgery,the study group was further divided into the visual impairment group(n=49)and the good visual acuity group(n=107),including 28 males and 21 females in the visual impairment group,with a mean age of 63.73±7.41 years,and 59 males and 48 females in the good visual acuity group,with a mean age of 59.24±8.47 years.The age and glycated hemoglobin(HbA1c)levels of the visual impairment group were higher than those of the good visual acuity group(all P<0.05).Compared with the good visual acuity group,the levels of SDF-1 and ENA78 in aqueous humor of the visual impairment group were significantly elevated(all P<0.05).A positive correlation was found in the study group between the levels of SDF-1,ENA78 in aqueous humor and HbA1c(r=0.314,0.362,all P<0.05).Elevated levels of aqueous humor SDF-1(OR=2.936,95%CI:1.628-5.296)and ENA78(OR=3.092,95%CI:1.738-5.502)were identified as risk factors for postoperative visual impairment in DR patients(all P<0.05).High levels of SDF-1 and ENA78 increased the risk of postoperative visual impairment by 1.958-fold and 2.030-fold compared with the low-level groups,respectively;the area under the curve(AUC)of combined detection of aqueous humor SDF-1 and ENA78 for predicting postoperative visual impairment in DR patients was 0.936,which was superior to the predictive value of SDF-1 or ENA78 alone(Zcombination-SDF-1=2.850,Zcombination-ENA78=2.445,all P<0.05). • CONCLUSION:Elevated levels of aqueous humor SDF-1 and ENA78 are risk factors for postoperative visual impairment in DR patients,and the combined detection of SDF-1 and ENA78 has high clinical application value for predicting postoperative visual impairment in DR patients.关键词
糖尿病视网膜病变(DR)/玻璃体切割术/基质细胞衍生因子1(SDF-1)/中性粒细胞激活肽-78(ENA78)/视力残疾/预测Key words
diabetic retinopathy(DR)/vitrectomy/stromal cell-derived factor 1(SDF-1)/epithelial neutrophil activating peptide-78(ENA78)/visual impairment/prediction引用本文复制引用
徐曼,郑嘉敏,钟文金..房水SDF-1与ENA78水平对DR患者玻璃体切割术后视力残疾的预测价值[J].国际眼科杂志,2026,26(3):493-498,6.基金项目
陕西省自然科学基础研究计划项目(No.2022JM-584) Shaanxi Provincial Natural Science Basic Research Program(No.2022JM-584) （No.2022JM-584）
