军事医学2026，Vol.50Issue(1)：31-35,5.DOI:10.7644/j.issn.1674-9960.2025-00021
基于云母和琼脂糖的复合止血凝胶海绵制备及其性能研究
Fabrication and characterization of mica-agarose composite hemostatic gel sponge
摘要
Abstract
Objective To develop a new hemostatic material that is both highly efficient and cost-effective using mica and agarose as raw materials.Methods A porous mica-agarose composite gel sponge was prepared via direct cross-linking,followed by freeze-drying.The microstructure was characterized by scanning electron microscopy(SEM).The influence of the mica content on pore size,water absorption,and volumetric swelling ratio was investigated.Hemostatic performance was assessed by measuring the hemolysis rate and blood clotting index,along with a mouse tail-amputation model.Results The prepared sponge exhibited a uniformly porous structure.Both water absorption and the volumetric swelling ratio increased with the mica content.However,excessive mica led to reduced stability of the pore structure.Biological evaluations revealed a hemolysis rate below 5%and a coagulation index of approximately 30%,suggesting favorable biocompatibility and effective hemostatic performance.Conclusion A composite hemostatic gel sponge based on mica and agarose has been developed,which promises wide applications in clinical hemostasis.关键词
云母/琼脂糖/复合凝胶/止血材料/矿物材料Key words
mica/agar/composite gel/hemostatic materials/mineral materials分类
医药卫生引用本文复制引用
周欣雨,杨忠委,王成,赵越,陈天姣,周树青,李海北,师丹阳,杨栋,赵来恩,金敏..基于云母和琼脂糖的复合止血凝胶海绵制备及其性能研究[J].军事医学,2026,50(1):31-35,5.基金项目
国家重点研发项目(2022YFC2604000) （2022YFC2604000）
