农药学学报2026，Vol.28Issue(1)：13-32,20.DOI:10.16801/j.issn.1008-7303.2025.0073
L-氮杂环丁烷-2-羧酸研究进展
Research advances in L-azetidine-2-carboxylic acid
摘要
Abstract
L-Azetidine-2-carboxylic acid(L-Aze)is a non-proteinogenic amino acid present in certain plant species.Characterized by unique azetidine structure(nitrogen-containing four-membered ring),this compound exhibits remarkable chemical reactivity and diverse physiological activities.Currently,the synthesis of L-Aze is mainly confined to chemical approaches,with diverse synthetic strategies having been reported.Notably,newly developed synthetic routes have achieved kilogram-scale production,indicating significant industrial production potential.Due to its a strained chiral azetidine ring system,L-Aze serves not only as a crucial building block for synthesizing chiral azetidine-containing natural products and bioactive pharmaceutical molecules,but also it has applications in chiral catalysis and pharmacophore design.Biological activity studies reveal that L-Aze can competitively mimic proline during protein synthesis,thereby disrupting normal protein metabolism.It exhibits broad inhibitory effects across diverse organisms,including plants,bacteria,viruses,fungi,and cyanobacteria,and also inhibits growth in multiple animal models.Notably,it demonstrates remarkable efficacy against cucurbit powdery mildew and potent inhibition of cyanobacteria,positioning it as a promising candidate for developing novel plant-derived fungicide.Furthermore,its rigid cyclic framework,an advantageous structural unit,has been extensively utilized in the structural modification and functional optimization of enzyme inhibitors,antimalarial drugs,and analgesics.This review summarizes the chemical synthesis and fungicidal activity of L-Aze,which can provide scientific basis for its development as a novel green pesticide.关键词
L-氮杂环丁烷-2-羧酸/手性氮杂环丁烷/瓜类白粉病/植物源杀菌剂/结构修饰Key words
L-azetidine-2-carboxylic acid/chiral azetidine/cucurbits powdery mildew/plant-derived fungicide/structural modification分类
化学化工引用本文复制引用
禹克银,张继文,吴文君..L-氮杂环丁烷-2-羧酸研究进展[J].农药学学报,2026,28(1):13-32,20.基金项目
中国博士后科学基金(No.2024M752643) （No.2024M752643）
西北农林科技大学科研启动费(No.2452022147). Supported by China Postdoctoral Science Foundation(No.2024M752643) （No.2452022147）
The Scientific Research Foundation of Northwest A&F University(No.2452022147). （No.2452022147）
