农药学学报2026，Vol.28Issue(1)：106-115,10.DOI:10.16801/j.issn.1008-7303.2025.0100
新型噻唑烷酮三氟乙基亚砜类化合物的设计、合成及杀螨活性
Design,synthesis and acaricidal activity of novel thiazolidinone containing trifluoroethyl sulfoxide compounds
摘要
Abstract
To discover new acaricides with high activities,25 novel thiazolidinones containing trifluoroethyl sulfoxide compounds were designed and synthesized based on the lead compound—spirothiazolidinones containing trifluoroethyl sulfide moiety,which was reported in our previous work.All the designed compounds were characterized by 1H NMR,13C NMR and HRMS.Acaricidal activity tests showed that some of the designed compounds exhibited more than 90%activity against Tetranychus cinnabarinus and T.urticae at a dosage of 100 mg/L.Notably,2-((2-fluoro-4-methyl-5-((2,2,2-trifluoroethyl)sulfinyl)phenyl)imino)-3-methyl-1-thia-3-azaspiro[4.4]nonan-4-one(IIIe)was effective against T.cinnabarinus with the lethal concentration 50(LC50)value of 3.8 mg/L,which exhibited higher activity than the lead compound(4.3 mg/L).This compound can serve as a promising candidate for further development as a new generation of high-efficacy acaricid.关键词
噻唑烷酮/三氟乙基硫醚/三氟乙基亚砜/杀螨活性Key words
thiazolidinone/trifluoroethyl sulfide/trifluoroethyl sulfoxide/acaricidal activity分类
化学化工引用本文复制引用
张世稳,蔡胜梅,陈锦彪,刘祈星,周海峰..新型噻唑烷酮三氟乙基亚砜类化合物的设计、合成及杀螨活性[J].农药学学报,2026,28(1):106-115,10.基金项目
顺毅股份有限公司研发项目(No.SDHZ2021215) （No.SDHZ2021215）
国家自然科学基金(No.22278244). Supported by Research and Development Project from Synwill Co.,Ltd.(No.SDHZ2021215),National Natural Science Foundation of China(No.22278244). （No.22278244）
