昆明医科大学学报2026，Vol.47Issue(2)：143-155,13.DOI:10.12259/j.issn.2095-610X.S20260215
CGRP介导的癌痛机制与靶向治疗研究进展
CGRP-mediated Cancer Pain Mechanisms and Targeted Therapeutic Approaches
摘要
Abstract
Calcitonin gene-related peptide(CGRP)exerts a central-peripheral synergistic amplification effect in the development and maintenance of cancer pain.This effect is mediated through the activation of signaling pathways,including NGF and BMP2,leading to increased sensory nerve excitability,the promotion of peripheral and central sensitization,and the formation of a"pain-tumor progression"positive feedback loop with the tumor microenvironment.Preclinical evidence has demonstrated the significant analgesic and anti-tumor potential of CGRP antagonists in models including breast cancer,oral cancer,and pancreatic cancer,among others.Furthermore,CGRP levels are closely correlated with cancer pain intensity,suggesting its potential value as a biomarker and intervention target for targeted cancer pain therapy.This review summarizes the mechanistic roles of CGRP in cancer pain and tumor progression,as well as recent advances in related therapeutic research,and explores future strategies for cancer pain management through targeting the CGRP pathway in combination with existing treatment modalities.关键词
降钙素基因相关肽/癌症相关疼痛/肿瘤微环境/靶向治疗/临床转化Key words
Calcitonin gene-related peptide/Cancer-related pain/Tumor microenvironment/Targeted therapy/Clinical translation分类
医药卫生引用本文复制引用
唐贝宁,邵世豪,李涛,沙运,杨谨源,皇甫泽京,顾欣宇,王忠慧..CGRP介导的癌痛机制与靶向治疗研究进展[J].昆明医科大学学报,2026,47(2):143-155,13.基金项目
国家自然科学基金(82350117 （）
32360046) （）
云南省临床医学中心项目(2024YNLCYXZX0399) （2024YNLCYXZX0399）
