华西口腔医学杂志2026，Vol.44Issue(1)：129-136,8.DOI:10.7518/hxkq.2026.2025174
2种含氟涂料对低龄儿童龋病社区干预的效果与成本分析
Efficacy and cost analysis of two fluoride varnishes in community-based interventions for early childhood caries
摘要
Abstract
Objective A community intervention mo-del was used to investigate the preventive effects and cost-effectiveness of I-ReHealth® and Duraphat® in early childhood caries.Methods Children from Yizhou Dis-trict,Hechi City,were enrolled and randomly assigned in-to two groups:the I-ReHealth® group and the Duraphat® group.Each group received topical fluoride varnish applications and dental health education every 6 months.After 1.5 years,the incidence of caries and associated costs were compared between the two groups before and after the interven-tion.Cost minimization analysis was employed to evaluate economic efficiency,and sensitivity analysis was performed to assess the influence of variations in key parameters on result stability and to quantify the probabilistic differences in cost benefits between the two fluoride varnishes under equivalent caries-preventive effects.Results Prior to the inter-vention,we found no statistically significant differences in caries prevalence or mean dmft scores between the two groups(P>0.05).After 1.5 years of treatment,both groups still showed no statistically significant differences in caries prevalence(P>0.05),mean dmft scores(P>0.05),caries incidence rate(P>0.05),or increment in mean dmft(P>0.05).The one-sided 97.5%confidence interval for the difference in mean dmft increment was below the non-inferiority thresh-old,confirming non-inferiority(P<0.025).Cost minimization analysis revealed lower total costs in the I-ReHealth® group(¥25 411.44)than in the Duraphat® group(¥26 692.98).One-way sensitivity analysis identified material price as the most influential parameter affecting total costs.Monte Carlo simulation with 1 000 iterations demonstrated a 73.1%probability that the I-ReHealth® group will yield cost savings compared with the Duraphat® group.Conclusion I-Re-Health® is non-inferior to Duraphat® in caries-preventive efficacy but superior in cost-effectiveness in reducing patient expenses.关键词
低龄儿童龋/含氟涂料/社区干预/成本最小化分析Key words
early childhood caries/fluoride varnish/community-based intervention/cost minimization analysis分类
医药卫生引用本文复制引用
杨朝青,余锦梅,张艺山,刘芳宏,庞秋玲,谢羽璐,冉翎杉,邱荣敏..2种含氟涂料对低龄儿童龋病社区干预的效果与成本分析[J].华西口腔医学杂志,2026,44(1):129-136,8.基金项目
Key Research and Development Project of Guangxi Science and Technology Department(AB22035015) （AB22035015）
Guangxi Medical and Health Appropriate Technology Development and Promotion and Application Project(S2020041,S2024121) （S2020041,S2024121）
Key Research and Development Program of Science and Technology Plan Project of Qingxiu District,Nan-ning(2020039) （2020039）
Scientific Research Project of Health Commission of Guangxi Zhuang Autonomous Region(Z-M20251725) 广西科技厅重点研发项目(AB22035015) （Z-M20251725）
广西医疗卫生适宜技术开发与推广应用项目(S2020041,S2024121) （S2020041,S2024121）
南宁市青秀区科技计划项目-重点研发计划(2020039) （2020039）
广西壮族自治区卫生健康委员会科研项目(Z-M20251725) （Z-M20251725）
