皮肤性病诊疗学杂志2026，Vol.33Issue(1)：9-15,7.DOI:10.3969/j.issn.1674-8468.2026.01.002
头皮控油平衡复合酸治疗头皮脂溢性皮炎的临床观察:一项单臂、开放性研究
A preliminary evaluation of the clinical efficacy of a sebum-regulating and balancing acid complex in the treatment of scalp seborrheic dermatitis:A single-arm,open-label study
摘要
Abstract
Objective To evaluate the clinical efficacy,safety,and mechanisms of a sebum-regulating and balancing acid complex in treating scalp seborrheic dermatitis(SSD).Methods Thirty eligible SSD patients were enrolled in this single-arm,open-label,self-controlled study.The intervention consisted of four weekly scalp acid peeling sessions.Subjective symptoms(oili-ness,itching,pain)were self-assessed by patients,while clinical signs(erythema,papules,scales)were evaluated by investigators via dermoscopy before each treatment.Fungal fluorescence staining of scalp scales was performed at baseline and post-treatment.Patients were followed up weekly for four weeks,starting two weeks after the last session.Results After four treatments,the subjective symptom scores(greasy sensation,itching,pain)and clinical sign scores(erythe-ma,scaling,papules)of the subjects significantly decreased(P＜0.01).The overall effective rate was 96.7%.Among the 27 patients who tested positive for fungi at baseline,12(44.44%)achieved complete fungal clearance after treatment.During the treatment period,two patients ex-perienced transient mild itching of the scalp and fever,which resolved spontaneously after 30 mi-nutes of observation,with no serious adverse reactions reported.During the 4-week follow-up,symptom and sign scores showed no significant changes(P＞0.05),except for a further improve-ment in erythema.Conclusions The compound acid treatment significantly ameliorates symptoms such as greasiness,itching,and pain in patients with SSD,as well as signs like erythema,pap-ules,and scales,while demonstrating good safety.关键词
头皮脂溢性皮炎/头皮控油平衡复合酸/头皮屏障/微生物屏障/单臂研究Key words
scalp seborrheic dermatitis/sebum-regulating and balancing acid complex/scalp barrier/microbial barrier/single-arm study引用本文复制引用
王有余,王海洪,张绍琴,江蕾微..头皮控油平衡复合酸治疗头皮脂溢性皮炎的临床观察:一项单臂、开放性研究[J].皮肤性病诊疗学杂志,2026,33(1):9-15,7.基金项目
国家自然科学基金地区基金(82160601,GPPH-NSFC-2021-13) （82160601,GPPH-NSFC-2021-13）
