南京医科大学学报（自然科学版）2026，Vol.46Issue(2)：262-269,298,9.DOI:10.7655/NYDXBNSN241225
肝脏磁共振成像质子密度脂肪分数诊断非酒精性脂肪性肝病的价值探讨
The diagnostic value of liver magnetic resonance imaging estimated proton density fat fraction in non-alcoholic fatty liver disease
摘要
Abstract
Objective:To investigate the pathological characteristics of patients with non-alcoholic fatty liver disease(NAFLD),their correlation with the magnetic resonance imaging estimated proton density fat fraction(MRI-PDFF)and liver function,and to explore the diagnostic value of MRI-PDFF in NAFLD.Methods:A total of 67 patients with NAFLD at the Department of Infectious Diseases,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine were recruited from June 1,2021 to August 30,2023.Clinical characteristics were retrospectively analyzed based on different pathological fat content and non-alcoholic fatty liver disease activity score(NAS).Correlations among pathological fat content,NAS,MRI-PDFF,body mass index(BMI),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)were examined.A total of 33 individuals without hepatic steatosis confirmed by liver pathology were included as controls.The diagnostic value of MRI-PDFF for NAFLD was analyzed by receiver operating characteristic(ROC)curve.Results:Age,BMI,ALT,AST,MRI-PDFF,and NAS scores showed significant differences among different levels of pathological fat content.Similarly,BMI,ALT,AST,and MRI-PDFF differed significantly among different NAS scores.Liver MRI-PDFF was significantly related to pathological fat content(r=0.775,P＜0.001),and moderately related to NAS(r=0.478,P＜0.001)and BMI(r=0.402,P=0.001).Compared with the control group,the area under the curve(AUC)of MRI-PDFF for diagnosing NAFLD was 0.989,with a sensitivity of 0.94,specificity of 0.97,and an optimal cutoff value of 4.42%.Conclusion:MRI-PDFF is a quantitative measurement that can accurately reflect liver fat content,suitable for dynamic assessment and therapeutic monitoring of hepatic steatosis.关键词
非酒精性脂肪性肝病/磁共振成像/质子密度脂肪分数Key words
non-alcoholic fatty liver disease/magnetic resonance imaging/proton density fat fraction分类
医药卫生引用本文复制引用
张帆,陆玮婷,史会连,陈沁磊,陈冉,乔飞,徐祥涛..肝脏磁共振成像质子密度脂肪分数诊断非酒精性脂肪性肝病的价值探讨[J].南京医科大学学报（自然科学版）,2026,46(2):262-269,298,9.基金项目
国家自然科学基金(82374360) （82374360）
