热带农业科学2026，Vol.46Issue(1)：115-122,8.DOI:10.12008/j.issn.1009-2196.2026.01.017
基于网络药理学探究胆木对白色念珠菌的抑制作用
Exploring the Inhibitory Effect of Nauclea officinalis on Candida albicans Based on Network Pharmacology
摘要
Abstract
This study employs network pharmacology,molecular docking,and antibacterial experiments to explore the key action targets and potential mechanisms by which the active components of the Li ethnic medicine N.officinalis inhibit Can-dida albicans.Targets of the active components of N.officinalis were obtained from the CNKI,PubMed,and SwissTarget databases,while C.albicans-related targets were retrieved from the DisGeNET database.The intersection of these targets was input into the STRING database to obtain core targets,which were then subjected to enrichment analysis,molecular docking,and experimental validation.The results showed that nine active components,258 corresponding targets,and 832 disease tar-gets were screened out,with 43 common targets obtained from the intersection,mainly including IL6,ALB,STAT3,PPARG,EGFR,etc.Enrichment analysis indicated that the pathways through which N.officinalis inhibits C.albicans infection mainly involve the regulation of inflammatory responses by antigen stimulation,the positive regulation of cytokine production in inflammatory responses,and inflammatory response pathways.Molecular docking revealed that the active components of N.officinalis can bind spontaneously to core proteins.Antibacterial experiment results showed that the N.officinalis extract reached MIC at 250 μg·mL-1.This study explored the active components and mechanisms of N.officinalis in treating C.albicans infection via network pharmacology,molecular docking,and antibacterial experiments and found that N.officinalis exerts therapeutic effects through multitarget,multicomponent,and multipathway actions.关键词
胆木/网络药理学/白色念珠菌/抑菌实验/分子对接Key words
Nauclea officinalis/network pharmacology/Candida albicans/antibacterial experiment/molecular docking分类
农业科技引用本文复制引用
吴小萍,张瀚铭,郑菀橘,曾琳,何丽敏,杨卫丽..基于网络药理学探究胆木对白色念珠菌的抑制作用[J].热带农业科学,2026,46(1):115-122,8.基金项目
海南省自然科学基金高层次人才项目"黎药胆木内生真菌微生态结构与其质量相关性研究"(No.820RC624) （No.820RC624）
大学生创新创业项目(No.S202311810007). （No.S202311810007）
