肿瘤预防与治疗2026，Vol.39Issue(2)：75-82,8.DOI:10.3969/j.issn.1674-0904.2026.02.001
靶向脂肪酸代谢重塑肿瘤免疫微环境:机制与免疫治疗新策略
Targeting Fatty Acid Metabolism to Reshape the Tumor Immune Microen-vironment:Mechanisms and Novel Immunotherapy Strategies
摘要
Abstract
The development and progression of tumors are closely associated with the interactions of multiple factors with-in their microenvironment,where fatty acid metabolism plays a pivotal role.Accumulating evidence indicates that fatty acids not only supply bioenergy and biosynthetic precursors for tumor cell proliferation and metastasis,but also regulate the func-tional states and phenotypic polarization of immune cells,thereby reshaping the immunosuppressive tumor immune microenvi-ronment(TIME).Particularly,fatty acid metabolism and its derivatives are now central to research on tumor immune eva-sion and resistance mechanisms.However,the relationship between fatty acid metabolism and TIME remains poorly under-stood,especially regarding the exploration of combined therapies targeting both metabolism and immunity.This study aims to analyze how fatty acid metabolism influences tumor immune responses by modulating immune cell function and modifying TIME.It summarizes current research advancements and potential therapeutic strategies,providing theoretical foundations for developing novel immunotherapy approaches.关键词
脂肪酸代谢/代谢重编程/肿瘤免疫微环境/免疫治疗/治疗策略Key words
Fatty acid metabolism/Metabolic reprogramming/Tumor immune microenvironment/Immunotherapy/Treat-ment strategy分类
医药卫生引用本文复制引用
陈丽华,王丁杰,孙蓬明..靶向脂肪酸代谢重塑肿瘤免疫微环境:机制与免疫治疗新策略[J].肿瘤预防与治疗,2026,39(2):75-82,8.基金项目
国家科技重大专项(编号:2025ZD0544102) （编号:2025ZD0544102）
福建省科技创新联合资金项目(编号:2024Y9587) This study was supported by grants from National Health Commission of the People's Republic of China(No.2025ZD0544102)and Science and Technology Department of Fujian Province(No.2024Y9587). （编号:2024Y9587）
